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Cancers of the Female Genital Tract
Female genital cancers consist of neoplasms with different characteristics for age of incidence, frequency, symptoms, aggressiveness, and prognosis....
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Co-emulsified Alginate-Eudragit Nanoparticles: Potential Carriers for Localized and Time-defined Release of Tenofovir in the Female Genital Tract
This research aimed to explore the possibilities of Eudragit S100 (ES100) and sodium alginate as carriers for tenofovir disoproxil fumarate (TDF) in...
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The features of high-risk human papillomavirus infection in different female genital sites and impacts on HPV-based cervical cancer screening
BackgroundThe causal role of high-risk Human papillomavirus (HR-HPV) in the pathogenesis of anogenital cancers is well established. In contrast,...
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Recurrent KRAS, KIT and SF3B1 mutations in melanoma of the female genital tract
BackgroundMalignant melanoma of the female genital tract is relatively uncommon and accounts for 3–7% of all melanoma localizations. This study aimed...
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Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection
BackgroundPrevious studies have shown that changes in the microbial community of the female urogenital tract are associated with Human papillomavirus...
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Oral-genital HPV infection transmission, concordance of HPV genotypes and genital lesions among spouses/ partners of patients diagnosed with HPV-related head and neck squamous cell carcinoma (HNSCC): a sco** review
BackgroundThere is an increase in number of Human Papillomavirus related head and neck squamous cell carcinoma (HPV-related HNSCC) High risk...
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Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa
BackgroundImmune function in the genital mucosa balances reproduction with protection against pathogens. As women age, genital infections, and...
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Size-dependent biodistribution of thiol-organosilica nanoparticles and F4/80 protein expression in the genital tract of female mice after intravaginal administration
Recently the vaginal route consider as an ideal route for drug delivery systems (DDS) administration. This is because, it is suitable for lower drug...
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Tissue-resident immunity in the female and male reproductive tract
The conception of how the immune system is organized has been significantly challenged over the last years. It became evident that not all...
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Geographic variation in urinary tract and genital cancers in Iran: a hypothesis involving exposure to solar radiation
ObjectiveSunlight and vitamin D intake are considered as essential elements for human health. Insufficient intake of this vitamin is one of the...
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Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
BackgroundCervicovaginal inflammation has been linked to negative reproductive health outcomes including the acquisition of HIV, other sexually...
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The impact of biological sex on diseases of the urinary tract
Biological sex, being female or male, broadly influences diverse immune phenotypes, including immune responses to diseases at mucosal surfaces. Sex...
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Microbial signatures and continuum in endometrial cancer and benign patients
BackgroundEndometrial cancer is a multifactorial disease with inflammatory, metabolic and potentially microbial cues involved in disease...
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Fatal multiple organ dysfunction caused by commensal bacteria of urogenital tract infection in adult lung transplant recipients: two case reports
BackgroundInfection following lung transplantation has been the focus of clinical concerns. The colonization rate of commensal bacteria of the...
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The human memory T cell compartment changes across tissues of the female reproductive tract
Memory CD4 T cells in tissues fulfill numerous functions that are critical for local immune homeostasis and protection against pathogens. Previous...
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Development of Immunocontraceptives in Female
Contraception is one of the ways of controlling population growth; however, contraceptive methods used today are not available to many individuals...
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Embryology of the Human Genital Tract
Before sexual differentiation begins at 7–8 weeks of gestation, the urogenital ridge develops on the posterior abdominal wall from the intermediate...
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Metagenomic analysis of the microbiome of the upper reproductive tract: combating ovarian cancer through predictive, preventive, and personalized medicine
PurposeWe investigated whether ovarian cancer could alter the genital microbiota in a specific way with clinical values. Furthermore, we proposed how...
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Immunohistochemical expression of PAX-8 in Sudanese patients diagnosed with malignant female reproductive tract tumors
ObjectivesPaired box protein-8 (PAX-8) immunohistochemical expression can be used as a diagnostic marker for epithelial cells tumors. This study...
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Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection
Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority...
