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Prominent and conspicuous astrocyte atrophy in human sporadic and familial Alzheimer’s disease
Pathophysiology of sporadic Alzheimer’s disease (SAD) and familial Alzheimer’s disease (FAD) remains poorly known, including the exact role of...
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Shared and unique effects of ApoEε4 and pathogenic gene mutation on cognition and imaging in preclinical familial Alzheimer’s disease
BackgroundNeuropsychology and imaging changes have been reported in the preclinical stage of familial Alzheimer’s disease (FAD). This study...
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Alzheimer’s Disease
Alzheimer’s disease (AD) represents the most prevalent form of senile dementias. The disease is characterized by the occurrence of extracellular...
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Epigenetic Therapy for Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no effective treatments. Increasing evidence suggests that the epigenetic...
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Amyloid-independent pathogenesis for Alzheimer’s disease: implications for drug design
Alzheimer’s disease (AD) is characterized pathologically by cerebral deposits of the amyloid β-peptide (Aβ), particularly the aggregation prone...
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Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease
Non-familial Alzheimer’s disease (AD) occurring before 65 years of age is commonly referred to as early-onset Alzheimer’s disease (EOAD) and...
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Pathophysiology and Management Approaches in Alzheimer’s Disease
Alzheimer’s disease is recognized as a progressive multifarious neurodegenerative disorder that is pathologically characterized by the deposition of...
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Introduction to Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative ailment associated with intracellular amyloid aggregates and extracellular...
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Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
BackgroundAging and sex are major risk factors for develo** late-onset Alzheimer’s disease. Compared to men, women experience worse...
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Lipid Profiling in Alzheimer’s Disease
The human brain is the organ with the most lipids after adipose tissues. The rich heterogeneity of the neural lipidome is being actively investigated...
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Biomarkers for Alzheimer’s Disease
Alzheimer’s disease is a neurodegenerative disease, which affects intellectually is frequently observed in elderly generations and genetically linked...
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One Train May Hide Another: Two Cases of Co-Occurring Primary Familial Brain Calcification and Alzheimer’s Disease
Primary familial brain calcification (PFBC) is a rare disorder that can manifest with a wide spectrum of motor, cognitive, and psychiatric symptoms...
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Myelin in Alzheimer’s disease: culprit or bystander?
Alzheimer’s disease (AD) is a neurodegenerative disorder with neuronal and synaptic losses due to the accumulation of toxic amyloid β (Αβ) peptide...
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Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity
The amyloid precursor protein (APP) is a key player in Alzheimer`s disease (AD) and the precursor of the Aβ peptide, which is generated by...
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Fat and Alzheimer’s Disease
Alzheimer’s disease is one of the devastating causes of increased mortality and morbidities worldwide. There are various causes and hypothetical...
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Targeting γ-secretase for familial Alzheimer’s disease
Familial Alzheimer’s disease (FAD) is a rare early-onset genetic form of common dementia of old age. Striking in middle age, FAD is caused by...
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Updates on mouse models of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the United States (US). Animal models, specifically mouse models have been...
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Step by Step Toward an Amyloid Beta Peptide-Based Hypothesis of Alzheimer’s Disease
Following the Alzheimer’s research decisive year 1987, the compass was set toward further exploration of the Amyloid–Alzheimer’s link. A great amount...
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Design of Therapeutic Nanomaterials for Amelioration of Alzheimer’s Disease
Alzheimer’s disease is the most common form of progressive late-onset dementia. The prevalence of multidimensional adversity of Alzheimer’s disease...