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Atypical extrapyramidal manifestation of a typical antipsychotic with serotonergic antidepressant
IntroductionTypical antipsychotics are known to produce extrapyramidal side effects such as drug induced parkinsonism, acute dystonia, akathisia,...
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POLR3A variants with striatal involvement and extrapyramidal movement disorder
Biallelic variants in POLR3A cause 4H leukodystrophy, characterized by hypomyelination in combination with cerebellar and pyramidal signs and...
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Reporting a rare form of myopathy, myopathy with extrapyramidal signs, in an Iranian family using next generation sequencing: a case report
BackgroundMyopathy with extrapyramidal signs (MPXPS) is an autosomal recessive mitochondrial disorder which is caused by mutation in mitochondrial...
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Correlation Between the SARA and A-T NEST Clinical Severity Scores in Adults with Ataxia-Telangiectasia
Ataxia-Telangiectasia (A-T) is an autosomal recessive neurodegenerative disease associated with cerebellar ataxia and extrapyramidal features. A-T...
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Efficacy of low-dose risperidone in combination with sertraline in first-episode drug-naïve patients with schizophrenia: a randomized controlled open-label study
ObjectiveDespite advances in pharmacology, the treatment of schizophrenia (SZ) remains a challenge due to relapse after antipsychotic discontinuation...
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Autoimmune parkinsonism with faciobrachiocrural dystonic seizures: a new phenotype of leucine-rich glioma-inactivated 1 (LGI1) autoimmunity
Extrapyramidal symptoms are seen in patients with leucine-rich glioma-inactivated 1 ( LGI1 ) antibody-positive patients infrequently and this can be...
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Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms
IntroductionWe explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS)...
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Managing Schizophrenia: A Challenge for Physicians
Schizophrenia is a dreaded mental disorder that causes the affected person to believe in distorted perceptions of reality and affects their quality...
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Comparative evaluation of clinical and cerebrospinal fluid biomarker characteristics in rapidly and non-rapidly progressive Alzheimer’s disease
BackgroundRapidly progressive forms of Alzheimer’s disease (rpAD) are increasingly recognized and may have a prevalence of up to 30% of patients...
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Histomorphological evaluations on the frontal cortex extrapyramidal cell layer following administration of N-Acetyl cysteine in aluminum induced neurodegeneration rat model
Aluminum is a potent neurotoxin used in animal models of neurodegenerative diseases like Alzheimer’s disease (AD), in which oxidative stress mediates...
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Spastic Paraplegia Type 7 (SPG7)
Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous disorders associated with different modes of inheritance and multiple loci and...
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L-Theanine adjunct to risperidone in the treatment of chronic schizophrenia inpatients: a randomized, double-blind, placebo-controlled clinical trial
RationaleInadequate responses to current schizophrenia treatments have accelerated research into novel therapeutic approaches.
Objectives ...
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Impact of aripiprazole discontinuation in remitted major depressive disorder: a randomized placebo-controlled trial
RationaleThe efficacy and safety of antidepressant augmentation therapy with aripiprazole (AATA) has been established; however, the ongoing effects...
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Long-term neurologic outcomes of COVID-19
The neurologic manifestations of acute COVID-19 are well characterized, but a comprehensive evaluation of postacute neurologic sequelae at 1 year has...
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Differences in the incidence of lurasidone adverse events between depressive disorders and schizophrenia in double-blind, randomized, placebo-controlled trials: a meta-analysis
RationaleWe conducted a meta-analysis of double-blind, randomized placebo-controlled trials of lurasidone (LUR) to examine the difference in the risk...
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Cerebellar cognitive-affective syndrome preceding ataxia associated with complex extrapyramidal features in a Turkish SCA48 family
SCA48 is a novel spinocerebellar ataxia (SCA) originally and recently characterized by prominent cerebellar cognitive-affective syndrome (CCAS) and...
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Ion Channel Genes and Ataxia
In this review we will discuss ataxic disorders attributed to mutations in ion channel genes. Such disorders seem to preferentially effect cerebellar...
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Extrapyramidal motor signs in older adults with HIV disease: frequency, 1-year course, and associations with activities of daily living and quality of life
Age and HIV disease have additive effects on neural systems that support motor functioning. The current study examined the combined impact of aging...
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Risk of renal impairment in atypical antipsychotics: a systematic review and meta-analysis
PurposeAtypical antipsychotics are associated with several adverse effects including metabolic syndrome, weight gain, QTc interval prolongation, and...
