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Locomotor Behavior and Memory Dysfunction Induced by 3-Nitropropionic Acid in Adult Zebrafish: Modulation of Dopaminergic Signaling
Huntington’s disease (HD) is a progressive neurodegenerative disease characterized by neuropsychiatric disturbance, cognitive impairment, and...
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Effects of the atypical antipsychotic and D3/D2 dopamine partial agonist cariprazine on effort-based choice behavior: implications for modeling avolition
RationaleCariprazine is an atypical antipsychotic that acts as a D3/D2 receptor partial agonist. In addition to treating positive symptoms of...
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Shifts in the neurobiological mechanisms motivating cocaine use with the development of an addiction-like phenotype in male rats
RationaleThe development of addiction is accompanied by a shift in the mechanisms motivating cocaine use from nucleus accumbens (NAc) dopamine D 1 ...
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The Adenosine A2A Receptor Activation in Nucleus Accumbens Suppress Cue-Induced Reinstatement of Propofol Self-administration in Rats
Propofol has shown strong addictive properties in rats and humans. Adenosine A2A receptors (A2AR) in the nucleus accumbens (NAc) modulate dopamine...
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Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
RationaleThe nucleus accumbens (NAc) core gates motivationally relevant behavioral action sequences through afferents from cortical and subcortical...
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Dopamine, activation of ingestion and evaluation of response efficacy: a focus on the within-session time-course of licking burst number
RationaleEvidence on the effect of dopamine D1-like and D2-like receptor antagonists on licking microstructure and the forced swimming response led...
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Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons
The plasticity of glutamatergic transmission in the ventral tegmental area (VTA) represents a fundamental mechanism in the modulation of dopamine...
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A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice
Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors, including feeding, but less is known about how these circuits may...
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Effort-related effects of chronic administration of the DA D2 receptor antagonist haloperidol via subcutaneous programmable minipumps: Reversal by co-administration of the adenosine A2A antagonist istradefylline
RationaleLong-acting antipsychotics such as haloperidol decanoate are becoming more commonly used. Long-acting depot formulations have several...
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Dopamine receptors regulate preference between high-effort and high-risk rewards
RationaleOptimal decision-making necessitates evaluation of multiple rewards that are each offset by distinct costs, such as high effort requirement...
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A stable gene set for prediction of prognosis and efficacy of chemotherapy in gastric cancer
BackgroundGastric cancer (GC) is a primary reason for cancer death in the world. At present, GC has become a public health issue urgently to be...
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Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target
Parkinson disease (PD) dementia, pathologically featured as nigrostriatal dopamine (DA) neuronal loss with motor and non-motor manifestations, leads...
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The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders
Historically, animal models have been routinely used in the characterization of novel chemical entities (NCEs) for various psychiatric disorders....
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Dopamine receptor D4 (DRD4) negatively regulates UCP1- and ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle cells
The activation of beige fat and muscle tissues is an interesting and encouraging target for therapeutic intervention in obesity owing to their...
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Screening Methods for the Evaluation of Antipsychotic Drugs
Psychotic disorder represents a spectrum of disorders ranging from delusional and brief psychotic disorders to schizoaffective disorder and chronic...
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Depression and Cancer: The Inflammatory Bridge
Depression has been associated with tumor pathogenesis, but the relationship between psychological factors and cancer development remains...
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Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects
Rationale and objectivesThe reinforcement-enhancing effect (REE) of nicotine refers to the drug’s ability to enhance the strength of other primary...
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Vigor, Effort-Related Aspects of Motivation and Anhedonia
In this chapter we provide an overview of the pharmacological and circuit mechanisms that determine the willingness to expend effort in pursuit of...
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Disruption of positive- and negative-feature morphine interoceptive occasion setters by dopamine receptor agonism and antagonism in male and female rats
RationaleInternally perceived stimuli evoked by morphine administration can form Pavlovian associations such that they can function as occasion...
