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Therapeutic Efficacy of Estrogen-Related Receptor β in Breast Carcinoma
Breast cancer mortality is fleeting in females worldwide. Numerous genetic, epigenetic, and environmental factors contribute to breast cancer...
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Therapeutic Efficacy of Estrogen-Related Receptor β in Breast Carcinoma
Breast cancer mortality is fleeting in females worldwide. Numerous genetic, epigenetic, and environmental factors contribute to breast cancer...
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Estrogen Up-Regulates Iron Transporters and Iron Storage Protein Through Hypoxia Inducible Factor 1 Alpha Activation Mediated by Estrogen Receptor β and G Protein Estrogen Receptor in BV2 Microglia Cells
Estrogen is a steroid hormone produced mainly by the ovaries. It has been found that estrogen could regulate iron metabolism in neurons and...
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Estrogen signaling via estrogen receptor alpha and its implications for neurodegeneration associated with Alzheimer’s disease in aging women
Estrogen receptor alpha (ERα) is a transcription factor activated by estrogenic hormones to regulate gene expression in certain organs, including the...
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Estrogen receptor β deficiency impairs gut microbiota: a possible mechanism of IBD-induced anxiety-like behavior
BackgroundAlthough the lack of estrogen receptor β (ERβ) is a risk factor for the development of inflammatory bowel disease (IBD) and psychiatric...
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All-trans-retinoic acid modulates glycolysis via H19 and telomerase: the role of mir-let-7a in estrogen receptor-positive breast cancer cells
BackgroundBreast cancer (BC) is the most commonly diagnosed cancer in women. Treatment approaches that differ between estrogen-positive (ER+) and...
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Endogenous estrogen receptor modulating oxysterols and breast cancer prognosis: Results from the MARIE patient cohort
Background27-hydroxycholesterol (HC) and 25-HC were identified as endogenous selective estrogen receptor modulators (SERMs) and estrogen receptor...
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Chronic Caffeine Consumption, Alone or Combined with Agomelatine or Quetiapine, Reduces the Maximum EEG Peak, As Linked to Cortical Neurodegeneration, Ovarian Estrogen Receptor Alpha, and Melatonin Receptor 2
RationaleEvidence of the effects of chronic caffeine (CAFF)-containing beverages, alone or in combination with agomelatine (AGO) or quetiapine...
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The Triad of Estrogen, Estrogen Receptors, and Colon Cancer
Colon cancer is one of the common malignancies in the developed world irrespective of the sexes. The incidence of colon cancer is increasing leaps...
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CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer
ObjectiveTo investigate CITED1 as a potential biomarker of anti-endocrine response and breast cancer recurrence, given its previously determined role...
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Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation
BackgroundEstrogen receptor β (ERβ) is the major ER subtype in hepatic stellate cells (HSCs). Previously we reported phytoestrogen calycosin...
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Nanomedicine in therapeutic warfront against estrogen receptor–positive breast cancer
Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide. Almost 70–80% of cases of BC are curable at the early...
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Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway
Chemotherapy can improve the prognosis and overall survival of breast cancer patients, but chemoresistance continues a major problem in clinical....
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Expression- and splicing-based multi-tissue transcriptome-wide association studies identified multiple genes for breast cancer by estrogen-receptor status
BackgroundAlthough several transcriptome-wide association studies (TWASs) have been performed to identify genes associated with overall breast cancer...
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The G Protein Estrogen Receptor (GPER) is involved in the resistance to the CDK4/6 inhibitor palbociclib in breast cancer
BackgroundThe cyclin D1-cyclin dependent kinases (CDK)4/6 inhibitor palbociclib in combination with endocrine therapy shows remarkable efficacy in...
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Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women
Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver disease and the prevalence is rising, especially in women....
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Estrogen receptor inhibition mediates radiosensitization of ER-positive breast cancer models
Endocrine therapy (ET) is an effective first-line therapy for women with estrogen receptor-positive (ER + ) breast cancers. While both ionizing...
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Patchouli alcohol as a selective estrogen receptor β agonist ameliorates AD-like pathology of APP/PS1 model mice
Clinical evidence shows that postmenpausal women are almost twice as likely to develop Alzheimer’s disease (AD) as men of the same age, and estrogen...
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Estrogen Receptor Alpha and ESR1 Mutations in Breast Cancer
The estrogen receptor alphaEstrogen receptor alpha (ERα) is a nuclear transcriptionTranscription factor that is expressed in more than 70% of all...
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Astragalin alleviates cognitive deficits and neuronal damage in SAMP8 mice through upregulating estrogen receptor expression
Senile plaques composed of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) composed of intracellular hyper-phosphorylated tau are major...
