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Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women
Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver disease and the prevalence is rising, especially in women....
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Progranulin, a moderator of estrogen/estrogen receptor α binding, regulates bone homeostasis through PERK/p-eIF2 signaling pathway
AbstractUnder normal conditions, the human body employs the synergistic action of osteoblasts and osteoclasts to maintain a dynamic balance between...
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Estrogen Up-Regulates Iron Transporters and Iron Storage Protein Through Hypoxia Inducible Factor 1 Alpha Activation Mediated by Estrogen Receptor β and G Protein Estrogen Receptor in BV2 Microglia Cells
Estrogen is a steroid hormone produced mainly by the ovaries. It has been found that estrogen could regulate iron metabolism in neurons and...
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Therapeutic Strategies to Target Activating Estrogen Receptor α Mutations
Breast cancer is a hormone-dependent disease. Despite great strides, estrogen receptor α (ER)-positive breast cancer remains a challenging disease....
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All-trans-retinoic acid modulates glycolysis via H19 and telomerase: the role of mir-let-7a in estrogen receptor-positive breast cancer cells
BackgroundBreast cancer (BC) is the most commonly diagnosed cancer in women. Treatment approaches that differ between estrogen-positive (ER+) and...
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Chronic Caffeine Consumption, Alone or Combined with Agomelatine or Quetiapine, Reduces the Maximum EEG Peak, As Linked to Cortical Neurodegeneration, Ovarian Estrogen Receptor Alpha, and Melatonin Receptor 2
RationaleEvidence of the effects of chronic caffeine (CAFF)-containing beverages, alone or in combination with agomelatine (AGO) or quetiapine...
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Estrogen receptor blockade and radiation therapy cooperate to enhance the response of immunologically cold ER+ breast cancer to immunotherapy
BackgroundMost patients with estrogen receptor positive (ER+) breast cancer do not respond to immune checkpoint inhibition (ICI); the tumor...
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Clinical Translation: Targeting the Estrogen Receptor
Estrogen Receptor alpha (ERα) stands as one of the most successfully prosecuted drug targets in oncology, beginning with the approval of tamoxifen...
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2′,3′,4′-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism
BackgroundMenopausal hormone therapy (MHT) is recommended for only five years to treat vasomotor symptoms and vulvovaginal atrophy because of safety...
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Estrogen Receptor Alpha and ESR1 Mutations in Breast Cancer
The estrogen receptor alphaEstrogen receptor alpha (ERα) is a nuclear transcriptionTranscription factor that is expressed in more than 70% of all...
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Sex-steroid hormones and risk of postmenopausal estrogen receptor-positive breast cancer: a case–cohort analysis
PurposeSex-steroid hormones are associated with postmenopausal breast cancer but potential confounding from other biological pathways is rarely...
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The Triad of Estrogen, Estrogen Receptors, and Colon Cancer
Colon cancer is one of the common malignancies in the developed world irrespective of the sexes. The incidence of colon cancer is increasing leaps...
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Involvement of the G-Protein-Coupled Estrogen Receptor-1 (GPER) Signaling Pathway in Neurodegenerative Disorders: A Review
The G-protein-coupled estrogen receptor-1 (GPER) is an extranuclear estrogen receptor that regulates the expression of several downstream signaling...
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The G Protein Estrogen Receptor (GPER) is involved in the resistance to the CDK4/6 inhibitor palbociclib in breast cancer
BackgroundThe cyclin D1-cyclin dependent kinases (CDK)4/6 inhibitor palbociclib in combination with endocrine therapy shows remarkable efficacy in...
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The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options
Hormonal therapy plays a vital part in the treatment of estrogen receptor–positive (ER +) breast cancer. ER can be activated in a ligand-dependent...
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Astragalin alleviates cognitive deficits and neuronal damage in SAMP8 mice through upregulating estrogen receptor expression
Senile plaques composed of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) composed of intracellular hyper-phosphorylated tau are major...
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Effects of Estrogen Receptor Antagonist ICI182.780 on a Rat Model of Traumatic Brain Injury
AbstractUnderstanding the roles of estrogen receptors (ERs) in the pathogenesis of traumatic brain injury (TBI) is an important topic of putative...
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Estrogen receptor beta expression in triple negative breast cancers is not associated with recurrence or survival
BackgroundTriple negative BCa (TNBC) is defined by a lack of expression of estrogen (ERα), progesterone (PgR) receptors and human epidermal growth...
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Estrogen-immuno-neuromodulation disorders in menopausal depression
A significant decrease in estrogen levels puts menopausal women at high risk for major depression, which remains difficult to cure despite its...
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The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells
BackgroundP-glycoprotein (P-gp), a member of the ATP Binding Cassette B1 subfamily (ABCB1), confers resistance to clinically relevant anticancer...
