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Therapeutic Efficacy of Estrogen-Related Receptor β in Breast Carcinoma
Breast cancer mortality is fleeting in females worldwide. Numerous genetic, epigenetic, and environmental factors contribute to breast cancer...
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Therapeutic Efficacy of Estrogen-Related Receptor β in Breast Carcinoma
Breast cancer mortality is fleeting in females worldwide. Numerous genetic, epigenetic, and environmental factors contribute to breast cancer...
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Estrogen signaling via estrogen receptor alpha and its implications for neurodegeneration associated with Alzheimer’s disease in aging women
Estrogen receptor alpha (ERα) is a transcription factor activated by estrogenic hormones to regulate gene expression in certain organs, including the...
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Estrogen Up-Regulates Iron Transporters and Iron Storage Protein Through Hypoxia Inducible Factor 1 Alpha Activation Mediated by Estrogen Receptor β and G Protein Estrogen Receptor in BV2 Microglia Cells
Estrogen is a steroid hormone produced mainly by the ovaries. It has been found that estrogen could regulate iron metabolism in neurons and...
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The prognostic value of MEK pathway–associated estrogen receptor signaling activity for female cancers
BackgroundOther than for breast cancer, endocrine therapy has not been highly effective for gynecologic cancers. Endocrine therapy resistance in...
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Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer
The ESR1 ligand binding domain activating mutations are the most prevalent genetic mechanism of acquired endocrine resistance in metastatic hormone...
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Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer
Patient-derived organoid models of estrogen receptor-positive (ER+) breast cancer would provide a much-needed tool to understand drug resistance and...
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Estrogen/HER2 receptor crosstalk in breast cancer: combination therapies to improve outcomes for patients with hormone receptor-positive/HER2-positive breast cancer
The human epidermal growth factor receptor 2 (HER2) is overexpressed in 13–22% of breast cancers (BC). Approximately 60–70% of HER2+ BC co-express...
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Protective role of estrogen through G-protein coupled receptor 30 in a colitis mouse model
Estrogen and its receptors are involved in the pathogenesis of gastrointestinal diseases such as colitis. However, the role of the membrane estrogen...
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Endogenous estrogen receptor modulating oxysterols and breast cancer prognosis: Results from the MARIE patient cohort
Background27-hydroxycholesterol (HC) and 25-HC were identified as endogenous selective estrogen receptor modulators (SERMs) and estrogen receptor...
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FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer
BackgroundObesity increases breast cancer risk and breast cancer-specific mortality, particularly for people with estrogen receptor (ER)-positive...
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Progranulin, a moderator of estrogen/estrogen receptor α binding, regulates bone homeostasis through PERK/p-eIF2 signaling pathway
AbstractUnder normal conditions, the human body employs the synergistic action of osteoblasts and osteoclasts to maintain a dynamic balance between...
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Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens
Parabens are used as preservatives in various household products, including oral products, cosmetics, and hair/body washes. In recent years, the...
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Clinical Translation: Targeting the Estrogen Receptor
Estrogen Receptor alpha (ERα) stands as one of the most successfully prosecuted drug targets in oncology, beginning with the approval of tamoxifen...
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The role of estrogen receptor manipulation during traumatic stress on changes in emotional memory induced by traumatic stress
RationaleTraumatic stress leads to persistent fear, which is a core feature of post-traumatic stress disorder (PTSD). Women are more likely than men...
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Chronic Caffeine Consumption, Alone or Combined with Agomelatine or Quetiapine, Reduces the Maximum EEG Peak, As Linked to Cortical Neurodegeneration, Ovarian Estrogen Receptor Alpha, and Melatonin Receptor 2
RationaleEvidence of the effects of chronic caffeine (CAFF)-containing beverages, alone or in combination with agomelatine (AGO) or quetiapine...
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CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer
ObjectiveTo investigate CITED1 as a potential biomarker of anti-endocrine response and breast cancer recurrence, given its previously determined role...
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Immune landscape of breast tumors with low and intermediate estrogen receptor expression
Immune checkpoint blockade (ICB) is currently approved for patients with triple-negative breast cancer (TNBC), whereas responses to ICB are also...
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Nanomedicine in therapeutic warfront against estrogen receptor–positive breast cancer
Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide. Almost 70–80% of cases of BC are curable at the early...
