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Enoxaparin for VTE thromboprophylaxis during inpatient rehabilitation care: assessment of the standard fixed dosing regimen
BackgroundWe aimed to examine the efficiency of fixed daily dose enoxaparin (40 mg) thromboprophylaxis strategy for patients undergoing inpatient...
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Comparison of edoxaban and enoxaparin in a rat model of AlCl3-induced thrombosis of the superior sagittal sinus
Cerebral sinus venous thrombosis (CSVT) is an uncommon disease that is usually treated with anticoagulation (heparin, low-molecular heparin, or...
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In vitro evaluation of anticoagulant therapy management when urgent percutaneous coronary intervention is required in rivaroxaban-treated patients
We investigated in vitro the management of intraprocedural anticoagulation in patients requiring immediate percutaneous coronary intervention (PCI)...
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A Novel Turn on Fluorescence Sensor for Determination Enoxaparin, a Low Molecular Weight Heparin
AbstractA sensor system was designed for the detection of Enoxaparin (Enox), a low molecular weight heparin (LMWH) that was run over the fluorescence...
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Permeation-Enhancing Nanoparticle Formulation to Enable Oral Absorption of Enoxaparin
This study tests the hypothesis that association complexes formed between enoxaparin and cetyltrimethylammonium bromide (CTAB) augment permeation...
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The Price and Market Share Evolution of the Original Biologics and Their Biosimilars in Finland
BackgroundBiological drugs are generally expensive and produce a continuously growing share of drug costs. Yet they are essential in the treatment of...
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Efficacy of the bleeding risk scoring system for optimal prophylactic anticoagulation therapy of venous thromboembolism in trauma patients: a single-center, retrospective, observational cohort study
BackgroundWe developed a bleeding risk scoring system (BRSS) using prophylactic anticoagulation therapy to comprehensively assess the risk of venous...
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Phase 1 study of GSK3368715, a type I PRMT inhibitor, in patients with advanced solid tumors
BackgroundGSK3368715, a first-in-class, reversible inhibitor of type I protein methyltransferases (PRMTs) demonstrated anticancer activity in...
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Commercial Low Molecular Weight Heparins — Patent Ecosystem and Technology Paradigm for Quality Characterization
Heparin is a subject of ever-growing interest for laboratory researchers and pharmaceutical industry. One of the driving factors is its critical...
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Case report – Gluteal hematoma in two spinal cord patients on enoxaparin for venous thromboembolism prophylaxis: evidence needed for a wiser choice
IntroductionAcute spinal cord injury is associated with an increased risk of thromboembolic events. Low-molecular-weight heparins are first-line...
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Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments
PurposeDespite the extensive vaccination campaigns in many countries, COVID-19 is still a major worldwide health problem because of its associated...
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Being precise with anticoagulation to reduce adverse drug reactions: are we there yet?
Anticoagulants are potent therapeutics widely used in medical and surgical settings, and the amount spent on anticoagulation is rising. Although...
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Assessment of drugs administered in the Middle East as part of the COVID-19 management protocols
The pandemic spread of coronavirus (COVID-19) has been reported first at the end of 2019. It continues disturbing various human aspects with multiple...
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Tinzaparin—a review of its molecular profile, pharmacology, special properties, and clinical uses
PurposeLow molecular weight heparins (LMWHs) are a group of heterogenous moieties, long used in the prevention and treatment of thrombosis. They...
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Patient involvement in pharmacovigilance: determinants and evolution of reporting from 2011 to 2020 in France
IntroductionBecause patients and patient organizations want to strengthen their role in the care pathway and drug evaluation and in order to improve...
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Mucoadhesive Drug Delivery System in Chronic Respiratory Diseases
The mucoadhesive drug delivery systems (MDDS) have the ability to bind fundamentally with the mucus membrane laid on respiratory tract, basically...
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Exploitation of Fibrinolytic Enzymes in Combating Blood Clotting Disorders – Recent Advances and Strategies: A Comprehensive Review
Formation of blood clumps inside vessels which restrict blood circulation throughout circulatory system is known as thrombosis. This leads to origin...
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Enoxaparin pretreatment effect on local and systemic inflammation biomarkers in the animal burn model
Low-molecular weight heparins (LMWH) are anticoagulants that have shown anti-inflammatory activity in several experimental models. Hot water burn...
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Scientific Considerations in the Approval of Complex Generics
A fundamental premise for generic approval is that the generic drug product contains the “same” active pharmaceutical ingredient as the brand name...
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Rivaroxaban for the treatment of cerebral venous thrombosis: a single-center experience
The mainstay of cerebral venous thrombosis (CVT) treatment according to current guidelines is parenteral anticoagulation with unfractionated heparin...