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ED Profiler: Machine Learning Tool for Screening Potential Endocrine-Disrupting Chemicals
Endocrine-disrupting chemicals (EDCs) could evoke untold endocrine-related detrimental effects on humans and wildlife. To minimize the potential...
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Metabolic effects of nuclear receptor activation in vivo after 28-day oral exposure to three endocrine-disrupting chemicals
Environmental exposure to endocrine-disrupting chemicals (EDCs) can lead to metabolic disruption, resulting in metabolic complications including...
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Immunomodulatory Effects of Endocrine-Disrupting Chemicals
Endocrine-disrupting chemicals or EDCs have become an integral part of human environment, be it in cosmetics, food, plastic packaging materials,...
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Combination of Donepezil and Memantine Attenuated Cognitive Impairment Induced by Mixed Endocrine-Disrupting Chemicals: an In Silico Study
Little is known about the effects of endocrine-disrupting chemicals (EDCs) and the combination of memantine and donepezil on the pathogenesis of...
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Thresholds of adversity for endocrine disrupting substances: a conceptual case study
For endocrine disrupting chemicals (EDC) the existence of “safe exposure levels”, that is exposure levels that do not present an appreciable risk to...
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Soluble Guanylyl Cyclase Alpha1 Subunit as a Biomarker of Toxicity: Applications to Investigate Endocrine-Disrupting Chemicals
Endocrine-disrupting chemicals (EDCs) are a growing group of naturally occurring and synthetic substances in the environment that negatively impacts...
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Cytotoxicity evaluation and mechanism of endocrine-disrupting chemicals by the embryoid body test
Endocrine-disrupting chemicals (EDCs) are a structurally diverse class of synthetic and natural compounds. EDCs can cause non-communicable diseases...
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Dirty Minds: How Endocrine Disrupting Chemicals (EDCs) and Other Pollutants Affect the Neuroendocrinology of Behavior and Emotions
Thousands of anthropogenic chemicals occupy our bodies and environment, a situation that imperils the health of present and future generations. This...
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Endocrine Disruptors
In the previous chapter, it is difficult to estimate the safe dose of carcinogenic chemicals by the traditional approach (NOAEL approach). The...
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Resveratrol, Endocrine Disrupting Chemicals, Neurodegenerative Diseases and Depression: Genes, Transcription Factors, microRNAs, and Sponges Involved
We aimed to examine the molecular basis of the positive effect of resveratrol against amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD),...
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Soluble Guanylyl Cyclase Alpha1 Subunit as a Biomarker of Toxicity: Applications to Investigate Endocrine-Disrupting Chemicals
Endocrine-disrupting chemicals (EDCs) are a growing group of naturally occurring and synthetic substances in the environment that negatively impacts...
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Racial/Ethnic Disparities in Pregnancy and Prenatal Exposure to Endocrine-Disrupting Chemicals Commonly Used in Personal Care Products
Purpose of ReviewEndocrine-disrupting chemical (EDC) exposure during pregnancy is linked to adverse maternal and child health outcomes that are...
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Effects of Environmental Endocrine-Disrupting Chemicals on Female Reproductive Health
Environmental endocrine-disrupting chemicals (EDCs) are xenobiotic compounds that are frequently contacted in daily life. With the species and...
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Linking Environmental Chemicals to Neuroinflammation and Autism Spectrum Disorder: Mechanisms and Implications for Prevention
This article explores the potential link between endocrine-disrupting chemicals (EDCs), neuroinflammation, and the development of autism spectrum...
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Epigenetic Chemicals
Epigenetic chemicals are chemical substances that exert their toxicity on individual inheritance through the epigenetic mechanism. In this chapter,...
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Toward the Integrated Health Risk Assessment of Chemicals
In previous chapters, there are chemicals categorized as carcinogenic, endocrine-disrupting, and nano-size substances. Estimating the safe dose of...
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Two novel in vitro assays to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins OATP1C1 and OAT4
Early brain development depends on adequate transport of thyroid hormones (THs) from the maternal circulation to the fetus. To reach the fetal brain,...
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Issue analysis: key characteristics approach for identifying endocrine disruptors
For more than a decade, weight of evidence (WoE) evaluations have been the standard method for determining whether a chemical meets the definition of...
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Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPARγ-bound fatty acids
Nuclear receptors (NRs) are key regulators of energy homeostasis, body development, and sexual reproduction. Xenobiotics binding to NRs may disrupt...
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