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Thresholds of adversity for endocrine disrupting substances: a conceptual case study
For endocrine disrupting chemicals (EDC) the existence of “safe exposure levels”, that is exposure levels that do not present an appreciable risk to...
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Endocrine Disruptors and Markers of Anthropogenic Activity: A Risk for Water Supply and Health
Numerous chemical substances are commonly used in everyday human activities. Some of these substances are considered micropollutants, with the...
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ED Profiler: Machine Learning Tool for Screening Potential Endocrine-Disrupting Chemicals
Endocrine-disrupting chemicals (EDCs) could evoke untold endocrine-related detrimental effects on humans and wildlife. To minimize the potential...
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Endocrine Disruptors and Markers of Anthropogenic Activity: A Risk for Water Supply and Health
Numerous chemical substances are commonly used in everyday human activities. Some of these substances are considered micropollutants, with the...
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Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?
Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs)...
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Development of Proliferative Response of Thymic Lymphocytes to T-Cell Mitogen in Rats Exposed to Endocrine Disrupter DDT during Ontogeny
We studied the formation of proliferative response of thymic lymphocytes to T-cell mitogen in rats exposed to endocrine disrupter DDT during prenatal...
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Bisphenol-F and Bisphenol-S (BPF and BPS) Impair the Stemness of Neural Stem Cells and Neuronal Fate Decision in the Hippocampus Leading to Cognitive Dysfunctions
Neurogenesis occurs throughout life in the hippocampus of the brain, and many environmental toxicants inhibit neural stem cell (NSC) function and...
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Regulation of Proliferative Processes in Rat Adrenal Cortex by Transcriptional Factor PRH under Conditions of Developmental Exposure to Endocrine Disruptor DDT
The effects of endocrine disrupters of transcriptional control of morphogenesis are poorly studied. Changes in the expression of transcriptional...
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The importance of toxic environmental substances in the development of thyroid cancer
Thyroid cancer is the most common cancer (90%) of the endocrine system and is responsible for 0.5% of all cancer deaths. The incidence of thyroid...
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Immune Homeostasis: A Novel Example of Teamwork
All living organisms must maintain homeostasis to survive, reproduce, and pass their traits on to the next generation. If homeostasis is not...
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Environmental Toxicology
Environmental toxicology investigates the adverse effects caused by natural and synthetic pollutants in all living organisms of ecosystems and at all...
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Safe Chemicals/REACH
Regulation (EC) No. 1907/2006 on Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) initiated a significant change in the...
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Ultrastructural Mechanisms of Impaired Aldosterone Synthesis in Rats Exposed to DDT during Prenatal and Postnatal Development
The study is aimed at elucidation of ultrastructural mechanisms underlying impaired aldosterone synthesis by glomerulosa cells in Wistar rats exposed...
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Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology
In Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) the criterion for deciding the studies that must be performed is the...
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The Role of Environmental Toxicant-Induced Oxidative Stress in Male Infertility
Infertility is a serious public health issue affecting around 15% of couples globally. Of the 60–80 million people of reproductive age affected by...
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Developmental exposure to low levels of ethinylestradiol affects social play in juvenile male rats
Juvenile social play contributes to the development of adult social and emotional skills in humans and non-human animals and is therefore a useful...
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Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids
BackgroundSex steroid hormone receptors are classified into three classes of receptors: estrogen receptors (ER) α and β, androgen receptor (AR), and...
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Neuroinflammation and Microglial Activation in Schizophrenia: An Overview
Schizophrenia has been classified recently to be initiated as a neuroinflammatory disorder that may upgrade later into neurodegenerative one. There...
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Trans-disciplinary diagnosis for an in-depth reform of regulatory expertise in the field of environmental toxicology and security
Repeated health and environmental scandals, the loss of biodiversity and the recent burst of chronic diseases constantly remind us the inability of...