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Resveratrol’s neural protective effects for the injured embryoid body and cerebral organoid
ObjectiveResveratrol (RSV) is a polyphenol compound found in grapes, veratrum and other plants. It has been reported that RSV has anti-inflammatory,...
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Cytotoxicity evaluation and mechanism of endocrine-disrupting chemicals by the embryoid body test
Endocrine-disrupting chemicals (EDCs) are a structurally diverse class of synthetic and natural compounds. EDCs can cause non-communicable diseases...
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Generation of Mini-Brains From hiPSCs
The high complexity of the human brain makes it hard to study in model organisms. In the meanwhile, due to the ethical issue, people have very...
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Human amniotic fluid stem cells are able to form embryoid body-like aggregates which performs specific functions: morphological evidences
Human second trimester Amniotic Fluid Stem Cells (hAFSCs) harbour the potential to differentiate into cells of each of the three germ layers and to...
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Comparative assessment of toxic responses in 3D embryoid body differentiation model and mouse early embryos treated with 5-hydroxytryptophan
Pluripotent stem cells recapitulate in vitro the early developmental stages and are considered promising cell models for predictive developmental...
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Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs
To meet the growing demand for developmental toxicity assessment of chemicals, New Approach Methodologies (NAMs) are needed. Previously, we developed...
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Subtype and Lineage-Mediated Protocol for Standardizing Activin/Nodal and BMP Signaling for hiPSC-Derived Cardiomyocyte Differentiation
The adept and systematic differentiation of embryonic stem cells (ESCs) and human-induced pluripotent stem cells (hiPSCs) to diverse lineage-prone...
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Strategies for differentiation of hiPSCs into dental epithelial cell lineage
Different stem cell–based strategies, especially induced pluripotent stem cells (iPSCs), have been exploited to regenerate teeth or restore...
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Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues
The generation of organoids and tissues with programmable cellular complexity, architecture and function would benefit from the simultaneous...
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Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Improve Mouse Status in Septic Peritonitis
We examined the efficacy of embryoid bodies from 6-day induced pluripotent stem cells an in vivo sepsis model. Injection of embryoid bodies to septic...
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Mitochondrial dynamics when mitochondrial toxic chemicals exposed in 3D cultured mouse embryonic stem cell
Mitochondria need to use considerable energy for the intracellular organelles that produce ATP. They are abundant in the cells of organs, such as...
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Hyperglycaemia-Induced Contractile Dysfunction and Apoptosis in Cardiomyocyte-Like Pulsatile Cells Derived from Mouse Embryonic Stem Cells
Hyperglycaemia, a key metabolic abnormality in diabetes mellitus, is implicated in pathological cardiogenesis during embryological development....
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A novel human pluripotent stem cell-based assay to predict developmental toxicity
There is a great need for novel in vitro methods to predict human developmental toxicity to comply with the 3R principles and to improve human...
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Generation of Human iPSC-Derived Retinal Organoids for Assessment of AAV-Mediated Gene Delivery
Human retinal organoids derived from induced pluripotent stem cells (iPSCs) serve as a promising preclinical model for testing the safety and...
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Isolation and Characterization of Stem Cells
Embryonic stem cells can be differentiated into all body cells. It was revealed that human embryonic stem cells can only be isolated from inner cell...
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Self-Organizing Brain Organoids with Ventricles Amenable to Injection and Electroporation
Brain organoids, or cerebral organoids, are a promising new tool to investigate neurodevelopment and disease in a human context. A variety of methods...
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Mitochondrial DNA mutation affects the pluripotency of embryonic stem cells with metabolism modulation
Mitochondria are the only organelles other than the nucleus harboring their DNA in mammalian cells. The mitochondrial DNA (mtDNA) mutation is the...
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Modeling HIV-1 infection and NeuroHIV in hiPSCs-derived cerebral organoid cultures
The human immunodeficiency virus (HIV) epidemic is an ongoing global health problem affecting 38 million people worldwide with nearly 1.6 million new...
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Cerebellar Modelling Using Human Induced Pluripotent Stem Cells
Human induced pluripotent stem cells (hiPSCs) have changed the way human development and disease are studied. It is now increasingly possible to...
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Alveolar epithelial-like cell differentiation in a dynamic bioreactor: a promising 3D-approach for the high-throughput generation of lung cell types from human induced pluripotent stem cells
PurposeHuman induced pluripotent stem cell (hiPSC)-derived lung cell types such as alveolar epithelial cells are promising for toxicological and...
