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Accurate detection of early-stage lung cancer using a panel of circulating cell-free DNA methylation biomarkers
BackgroundLung cancer remains the leading cause of cancer mortality worldwide. Early detection of lung cancer helps improve treatment and survival....
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Red blood cell distribution width is associated with sarcopenia risk in early-stage non-small cell lung cancer
BackgroundSarcopenia has received increasing attention in non-small cell lung cancer (NSCLC). Red blood cell distribution width (RDW) is a...
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Immunobiology of Lung Cancer
Lung cancer still has a bad prognosis, despite a reducing incidence. The absence of early detection and the recent advancements in targeted cancer...
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Stereotactic ablative brachytherapy versus percutaneous microwave ablation for early-stage non-small cell lung cancer: a multicenter retrospective study
BackgroundTo analyze the efficacy of stereotactic ablative brachytherapy (SABT) and percutaneous microwave ablation (MWA) for the treatment of...
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Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer
BackgroundTo explore the possible carcinogenesis and help better diagnose and treat patients with synchronous multiple primary lung cancers (sMPLC),...
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Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer
PurposeThis study aimed to compare the outcomes of patients with ground-grass opacity (GGO)-dominant non-small cell lung cancer (NSCLC) who were...
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Stereotactic body radiotherapy for early-stage lung cancer: a systematic review on the choice of photon energy and linac flattened/unflattened beams
SBRT is an effective local treatment for patients with early-stage non-small cell lung cancer (NSCLC). This treatment is currently used in patients...
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Survival analysis after stereotactic ablative radiotherapy for early stage non-small cell lung cancer: a single-institution cohort study
BackgroundStereotactic ablative radiotherapy (SABR) is the standard treatment for medically inoperable early-stage non-small cell lung cancer...
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Lung Cancer
Lung cancer has a complex pathophysiology and is one of the leading causes of death all over the world. Cutting edge imaging modalities and omics...
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Comparison of long-term outcomes of stereotactic body radiotherapy (SBRT) via Helical tomotherapy for early-stage lung cancer with or without pathological proof
BackgroundStereotactic body radio therapy (SBRT) has emerged as a standard treatment option for nonsurgical candidates with early-stage non-small...
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Introduction to Lung Cancer
Lung cancer is the second most common malignancy in both men and women. In total, 90% of lung cancer–related fatalities are caused by smoking, which...
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Association of neutrophil–lymphocyte ratio with survival in peripheral early-stage non-small cell lung cancer after stereotactic body radiation therapy
BackgroundThe role of neutrophil–lymphocyte ratio (NLR) as a predictor for survival in single fraction SBRT-treated non-small cell lung cancer...
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Novel genome-wide DNA methylation profiling reveals distinct epigenetic landscape, prognostic model and cellular composition of early-stage lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD) has been a leading cause of cancer-related mortality worldwide. Early intervention can significantly improve...
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Multi-omics integrative modelling for stereotactic body radiotherapy in early-stage non-small cell lung cancer: clinical trial protocol of the MONDRIAN study
BackgroundCurrently, main treatment strategies for early-stage non-small cell lung cancer (ES-NSCLC) disease are surgery or stereotactic body...
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A PET/CT radiomics model for predicting distant metastasis in early-stage non–small cell lung cancer patients treated with stereotactic body radiotherapy: a multicentric study
ObjectivesStereotactic body radiotherapy ( SBRT) is a treatment option for patients with early-stage non-small cell lung cancer (NSCLC) who are unfit...
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Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls
BackgroundMetabolomics is a potential means for biofluid-based lung cancer detection. We conducted a non-targeted, data-driven assessment of plasma...
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Association of the SHOX2 and RASSF1A methylation levels with the pathological evolution of early-stage lung adenocarcinoma
Background The methylation of SHOX2 and RASSF1A shows promise as a potential biomarker for the early screening of lung cancer, offering a solution to...
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Association of antibiotic exposure with residual cancer burden in HER2-negative early stage breast cancer
Antibiotic exposure during immunotherapy (IO) has been shown to negatively affect clinical outcomes in various cancer types. The aim of this study...
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Transcriptomic landscape based on annotated clinical features reveals PLPP2 involvement in lipid raft-mediated proliferation signature of early-stage lung adenocarcinoma
BackgroundImage-based screening improves the detection of early-stage lung adenocarcinoma (LUAD)but also highlights the issue of high false-positive...
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Associations between detectable circulating tumor DNA and tumor glucose uptake measured by 18F-FDG PET/CT in early-stage non-small cell lung cancer
BackgroundThe low level of circulating tumor DNA (ctDNA) in the blood is a well-known challenge for the application of liquid biopsies in early-stage...
