Search
Search Results
-
A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge
BackgroundHuman enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis,...
-
Effects and mechanism of Aβ1−42 on EV-A71 replication
Backgroundβ-Amyloid (Aβ) protein is a pivotal pathogenetic factor in Alzheimer’s disease (AD). However, increasing evidence suggests that the brain...
-
The Characteristics of EV-A71-CV-A16 Infection and Interaction with a Host
Recently, the number of HFMD outbreaks in the Asia–Pacific region has been increasing every year. Relationship between EVs and activation of the host...
-
An auto-antibody identified from phenotypic directed screening platform shows host immunity against EV-A71 infection
BackgroundEnterovirus A71 (EV-A71) is a neurotropic virus which may cause severe neural complications, especially in infants and children. The...
-
DNA aptamer against EV-A71 VP1 protein: selection and application
BackgroundEnterovirus 71 (EV-A71) is a highly infectious pathogen associated with hand, foot and mouth disease, herpangina, and various neurological...
-
Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained macrophage immunity
Virus-induced asthma is prevalent among children, but its underlying mechanisms are unclear. Accumulated evidence indicates that early-life...
-
Research and Development of HFMD Vaccines
HFMD is a viral contagious disease that occurs most often in children under 5 years old (Zhang et al. Emerg Microbes Infect 4(2):e12, 2015). It is a...
-
Research progress on pathogenic and therapeutic mechanisms of Enterovirus A71
In recent years, enterovirus A71 (EV-A71) infection has become a major global public health problem, especially for infants and young children. The...
-
Genomic epidemiology of CVA10 in Guangdong, China, 2013–2021
Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness primarily affecting children globally. A significant epidemiological...
-
Enterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis
BackgroundEnterovirus 71 (EV-A71) causes Hand, Foot and Mouth Disease (HFMD) in children and has been associated with neurological complications. The...
-
Etiology of HFMD
Hand, foot, and mouth disease (HFMD) is caused by multiple viruses in the genus Enterovirus, which include the well-known polioviruses (PVs),...
-
MicroRNA 876-5p modulates EV-A71 replication through downregulation of host antiviral factors
BackgroundHuman enterovirus 71 (EV-A71) is a non-enveloped virus that has a single stranded positive sense RNA genome. In a previous study, we showed...
-
Seroprevalence of coxsackievirus A6 and enterovirus A71 infection in humans: a systematic review and meta-analysis
Hand, foot, and mouth disease (HFMD) is a common infectious disease in children. Enterovirus A71 (EV-A71) is one of the main pathogens, and...
-
Molecular epidemiology and clinical characteristics of enteroviruses associated HFMD in Chengdu, China, 2013–2022
ObjectivesThis study aims to investigate molecular epidemiology and clinical characteristics of enterovirus associated hand-foot-mouth disease (HFMD)...
-
Recent advances in enterovirus A71 pathogenesis: a focus on fatal human enterovirus A71 infection
Enterovirus A71 (EV-A71) is one of the major pathogens responsible for hand, foot, and mouth disease (HFMD). Many HFMD outbreaks have been reported...
-
Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model
BackgroundEnterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV-A71 were...
-
Pathogen–Host Interaction and Its Associated Molecular Mechanism in HFMD Pathology and Immunology
Hand, foot, and mouth disease (HFMD) is caused by the enterovirus family, which includes EV-A71 and more than 10 other members. The disease involves...
-
Current status of hand-foot-and-mouth disease
Hand-foot-and-mouth disease (HFMD) is a viral illness commonly seen in young children under 5 years of age, characterized by typical manifestations...
-
Cellular Caspase-3 Contributes to EV-A71 2Apro-Mediated Down-Regulation of IFNAR1 at the Translation Level
Enterovirus A71 (EV-A71) is the major pathogen responsible for the severe hand, foot and mouth disease worldwide, for which few effective antiviral...
-
Molecular characteristics of a coxsackievirus A12 strain in Zhejiang of China, 2019
BackgroundEnterovirus A (EV-A), such as enterovirus A71 (EV-A71), generally causes hand, foot, and mouth disease (HFMD). However, limited studies...
