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TRIM26 inhibits clear cell renal cell carcinoma progression through destabilizing ETK and thus inactivation of AKT/mTOR signaling
BackgroundTripartite motif-containing 26 (TRIM26), a member of the TRIM protein family, exerts dual function in several types of cancer....
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Ibrutinib combination therapy for advanced gastrointestinal and genitourinary tumours: results from a phase 1b/2 study
BackgroundIbrutinib, a first-in-class inhibitor of Bruton’s tyrosine kinase, is approved for the treatment of various B-cell malignancies and chronic...
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Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer
Liver cancer is a major malignant tumor, which seriously threatens human health and increases the economic burden on patients. At present, gene...
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Oral Microbiome in Oral Squamous Cell Carcinoma
In recent years, studies have shown that like many other diseases, oral cancer initiation and progression is influenced by a cocktail of host...
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The identification of a two-gene prognostic model based on cisplatin resistance-related ceRNA network in small cell lung cancer
BackgroundSmall cell lung cancer (SCLC) is a very malignant tumor with rapid growth and early metastasis. Platinum-based chemo-resistance is the...
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Current Treatment Modalities Targeting Tumor Microenvironment in Castration-Resistant Prostate Cancer
Prostate cancer (PCa) is responsible for significant cancer-related morbidity and mortality following local treatment failure in men. The initial...
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Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway
Radiotherapy is the backbone of nasopharyngeal carcinoma (NPC), nearly 11–17% NPC patients suffered local relapse and 18–37% suffered distant...
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Impact of a short-term nitrate and citrulline co-supplementation on sport performance in elite rowers: a randomized, double-blind, placebo-controlled crossover trial
PurposeCitrulline (CIT) and beetroot extract (BR) have separately shown benefits in rowing performance-related outcomes. However, effects of combined...
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Role of PIM Kinase Inhibitor in the Treatment of Alzheimer’s Disease
Alzheimer’s disease (AD), a neurodegenerative disorder, is the most prevalent form of senile dementia, causing progressive deterioration of...
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Bacteria-Induced Carcinopathogenesis in Oral Squamous Cell Carcinoma
The human oral microbiome plays an important role in host physiology. The causes and factors that influence the microbiota are closely linked to the...
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Zanubrutinib: past, present, and future
In recent years, Bruton tyrosine kinase (BTK) inhibitors have provided significant advances in the treatment of patients with B-cell malignancies....
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Functional map** of the somatosensory cortex using noninvasive fMRI and touch in awake dogs
Dogs are increasingly used as a model for neuroscience due to their ability to undergo functional MRI fully awake and unrestrained, after extensive...
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Interleukin-6 Function and Targeting in Prostate Cancer
Interleukin-6 (IL-6) is a proinflammatory cytokine, which is involved in pathogenesis of several cancers. Its expression and function in prostate...
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The Role of Cytokines in Maintaining the Dynamics of Cell—Cell Interaction between Natural Killer Cells and Trophoblast Cells
We analyzed the effect of individual cytokines that are secretory products of placenta typical of the uteroplacental bed. The proinflammatory...
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As a prognostic biomarker of clear cell renal cell carcinoma RUFY4 predicts immunotherapy responsiveness in a PDL1-related manner
BackgroundClear cell renal cell carcinoma (ccRCC) is one of the most lethal malignancies in the urinary system and the existing immunotherapy has not...
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Bacterial Protein Kinases
Bacteria are able to inhabit and survive vastly diverse environments. This enormous adaptive capacity depend on their ability to perceive cues from...
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Microbe-Induced Oxidative Stress in Cancer Development and Efficacy of Probiotics as Therapeutics in Preventing Its Onset and Progression
Within the metaorganisms, cross-communication between commensal organisms and the host is crucial for the maintenance of physiological homeostasis....
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Microbe-Induced Oxidative Stress in Cancer Development and Efficacy of Probiotics as Therapeutics in Preventing Its Onset and Progression
Within the metaorganisms, cross-communication between commensal organisms and the host is crucial for the maintenance of physiological homeostasis....