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Biophysical Regulation of TGFβ Signaling in the Tumor Microenvironment
Transforming growth factor (TGF)-β is a multifunctional cytokine that contributes to epithelial–mesenchymal transition, tumor development, and...
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Mesenchymal stromal cell senescence in haematological malignancies
Acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), and multiple myeloma (MM) are age-related haematological malignancies with...
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A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans
BackgroundDuring pregnancy, the mouse mammary ductal epithelium branches and grows into the surrounding stroma, requiring extensive extracellular...
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Electromagnetic Modulation of Cell Behavior: Unraveling the Positive Impacts in a Comprehensive Review
There are numerous effective procedures for cell signaling, in which humans directly transmit detectable signals to cells to govern their essential...
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Potential Applications of Static Magnetic Fields in Cancer Treatment
This chapter lists current evidence (from molecular level, cellular level, animal level to patient level) and some potential mechanisms for the...
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Pyroptosis in bone loss
Pyroptosis could be responsible for the bone loss from bone metabolic diseases, leading to the negative impact on people's health and life. It has...
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Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin
BackgroundAs in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some...
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Magnetic Field Parameters and Biological Sample Differences That Lead to Differential Bioeffects
We have to admit that the literature concerning bioeffects of electromagnetic fields is replete with reports that cannot be reproduced in other labs....
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Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression
Mycotoxins induce oxidative stress, hypoxia, and cause immunosuppressive effects. Moreover, emerging evidence show that mycotoxins have a potential...
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Skeletal muscle reprogramming by breast cancer regardless of treatment history or tumor molecular subtype
Increased susceptibility to fatigue is a negative predictor of survival commonly experienced by women with breast cancer (BC). Here, we sought to...
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Interaction between non-coding RNAs, mRNAs and G-quadruplexes
G-quadruplexes are secondary helical configurations established between guanine-rich nucleic acids. The structure is seen in the promoter regions of...
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Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by progressive memory decline and cognitive dysfunctions. Although the...
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Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow
Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α (IFN-α) family. IFN-α2b has beneficial antiviral, antitumour,...
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Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin
BackgroundWhile exposure to diesel exhaust particles has been linked to aberrant immune responses in allergic diseases such as asthma, little...
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Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system
BackgroundBreast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integrins/integrin-linked...
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Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells
BackgroundHepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Complete epithelial to mesenchymal...
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Long-range enhancer–promoter contacts in gene expression control
Spatiotemporal gene expression programmes are orchestrated by transcriptional enhancers, which are key regulatory DNA elements that engage in...
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Unmasking senescence: context-dependent effects of SASP in cancer
Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue culture artefact by some researchers, senescence is now a...
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BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer
BackgroundAngiogenesis has become an attractive target for cancer therapy. However, despite the initial success of anti-VEGF (Vascular endothelial...
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Pathobiology of the 129:Stat1 −/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype
BackgroundStat1 gene-targeted knockout mice (129S6/SvEvTac- Stat1 tm1Rds ) develop estrogen receptor-positive (ER + ), luminal-type mammary carcinomas...
