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Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson’s disease
Deficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are...
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Circulating extracellular vesicles are associated with pathophysiological condition including metabolic syndrome-related dysmetabolism in children and adolescents with obesity
AbstractObesity of children and adolescents (OCA) is often accompanied by metabolic syndrome (MetS), which often leads to adult obesity and...
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Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer
Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent...
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Novel Pathogenic Mutation of P209L in TRPC6 Gene Causes Adult Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a leading kidney disease, clinically associated with proteinuria and progressive renal failure. The...
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Membrane protein trafficking in the anti-tumor immune response: work of endosomal-lysosomal system
Immunotherapy has changed the treatment landscape for multiple cancer types. In the recent decade, great progress has been made in immunotherapy,...
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Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling
BackgroundNon-small cell lung cancer (NSCLC) is a devastating disease with a heterogeneous prognosis, and the molecular mechanisms underlying tumor...
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Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
BackgroundGenetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer’s disease risk. Neurons express Pyk2 and the protein...
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Knockout mice with pituitary malformations help identify human cases of hypopituitarism
BackgroundCongenital hypopituitarism (CH) and its associated syndromes, septo-optic dysplasia (SOD) and holoprosencephaly (HPE), are midline defects...
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Revealing Genotype–Phenotype Interactions: The AgroLD Experience and Challenges
Understanding genotype–phenotype relationships is one of the most important areas of research in agronomy. The new challenges aim at understanding...
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Introduction to MicroRNAs
MiRNAs are small noncoding RNAs ranging in length from 20 to 22 nucleotides. They are documented to be involved in complex cellular process from cell...
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Kavain ablates the radio-resistance of IDH-wildtype glioblastoma by targeting LITAF/NF-κB pathway
BackgroundGlioblastoma multiforma (GBM) is the most malignant intrinsic tumor of the central nervous system (CNS), with high morbidity of...
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The Evolutionary Aspects of Flowering Control: Florigens and Anti-Florigens
AbstractFor successful survival and reproduction in various environmental conditions, over the course of evolution, plants have formed a complex of...
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Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes
Living organisms constantly need to adapt to their surrounding environment and have evolved sophisticated mechanisms to deal with stress....
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Horizontal mitochondrial transfer as a novel bioenergetic tool for mesenchymal stromal/stem cells: molecular mechanisms and therapeutic potential in a variety of diseases
Intercellular mitochondrial transfer (MT) is a newly discovered form of cell-to-cell signalling involving the active incorporation of healthy...
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Potassium Channel KCNH1 Activating Variants Cause Altered Functional and Morphological Ciliogenesis
The primary cilium is a non-motile sensory organelle that extends from the surface of most vertebrate cells and transduces signals regulating...
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Reverse genetic approaches for breeding nutrient-rich and climate-resilient cereal and food legume crops
In the last decade, advancements in genomics tools and techniques have led to the discovery of many genes. Most of these genes still need to be...
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CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation
BackgroundCoronavirus-induced disease 19 (COVID-19) infects more than three hundred and sixty million patients worldwide, and people with severe...
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Genetic regulation and variation of expression of miRNA and mRNA transcripts in fetal muscle tissue in the context of sex, dam and variable fetal weight
BackgroundImpaired skeletal muscle growth in utero can result in reduced birth weight and pathogenesis of intrauterine growth restriction. Fetal and...
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Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet
Broomcorn millet ( Panicum miliaceum L.) is an orphan crop with the potential to improve cereal production and quality, and ensure food security. Here...
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Adaptive stress response genes associated with breast cancer subtypes and survival outcomes reveal race-related differences
Aggressive breast cancer variants, like triple negative and inflammatory breast cancer, contribute to disparities in survival and clinical outcomes...
