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A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice
Alzheimer’s disease (AD) has a complex etiology, which requires a multifactorial approach for an efficient treatment. We have focused on E2 factor 4...
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E2F4-Based Gene Therapy Mitigates the Phenotype of the Alzheimer’s Disease Mouse Model 5xFAD
After decades of unfruitful work, no effective therapies are available for Alzheimer’s disease (AD), likely due to its complex etiology that requires...
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Roles of E2F family members in the diagnosis and prognosis of head and neck squamous cell carcinoma
BackgroundHead and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide. E2Fs are a group of transcription factors...
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Tumor microenvironment deconvolution identifies cell-type-independent aberrant DNA methylation and gene expression in prostate cancer
BackgroundAmong men, prostate cancer (PCa) is the second most common cancer and the second leading cause of cancer death. Etiologic factors...
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The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding
AbstractEN1 encodes a homeodomain-containing transcription factor and is a determinant of bone density and fracture. Previous powerful genome-wide...
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Potential Signature Therapeutic Biomarkers TOP2A, MAD2L1, and CDK1 in Colorectal Cancer: A Systems Biomedicine-Based Approach
Colorectal cancer is the third deadliest and fourth most diagnosed cancer. It is heterogeneously driven by varied mutations and mutagens, and thus,...
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ZMIZ2 promotes the development of triple-receptor negative breast cancer
BackgroundTriple-receptor negative breast cancer (TNBC) is an aggressive breast tumor subtype that generally has a poor prognosis. This study aimed...
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Prognostic role of E2F1 gene expression in human cancer: a meta-analysis
ObjectiveE2F1 has been confirmed to be highly expressed in a variety of cancers. To better understand the prognostic value of E2F1 in cancer...
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Long non-coding RNA GAS5 inhibits DDP-resistance and tumor progression of epithelial ovarian cancer via GAS5-E2F4-PARP1-MAPK axis
BackgroundEpithelial ovarian cancer (EOC) is the malignant tumor of the female reproductive system with the highest fatality rate. Tolerance of...
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Distinct genome-wide DNA methylation and gene expression signatures in classical monocytes from African American patients with systemic sclerosis
BackgroundSystemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects women and African...
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HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer
BackgroundMost cancer cells have fundamentally different metabolic characteristics, particularly much higher glycolysis rates than normal tissues,...
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Combination of Donepezil and Memantine Attenuated Cognitive Impairment Induced by Mixed Endocrine-Disrupting Chemicals: an In Silico Study
Little is known about the effects of endocrine-disrupting chemicals (EDCs) and the combination of memantine and donepezil on the pathogenesis of...
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ZBTB7A, a potential biomarker for prognosis and immune infiltrates, inhibits progression of endometrial cancer based on bioinformatics analysis and experiments
BackgroudZBTB protein is an important member of the C2H2 zinc finger protein family. As a transcription factor, it is widely involved in the...
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NNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer
BackgroundNeuronatin (NNAT) was recently identified as a novel mediator of estrogen receptor-positive (ER+) breast cancer cell proliferation and...
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Longitudinal CTCs gene expression analysis on metastatic castration-resistant prostate cancer patients treated with docetaxel reveals new potential prognosis markers
CTCs have extensively been used for the monitoring and characterization of metastatic prostate cancer, but their application in the clinic is still...
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A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis of hepatocellular carcinoma
BackgroundCircRNAs participate in the development of hepatocellular carcinoma (HCC). This work aims to explore the key tumor promoting circRNA as a...
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Mild dyserythropoiesis and β-like globin gene expression imbalance due to the loss of histone chaperone ASF1B
The expression of the human β-like globin genes follows a well-orchestrated developmental pattern, undergoing two essential switches, the first one...
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Tumorsuppressorgene
Tumorsuppressorgene sind die zweite wichtige Klasse von Krebsgenen. Im Gegensatz zu Onkogenen müssen Tumorsuppressorgene in ihrer Funktion...
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Characterization of a pathogenic variant in GBA for Parkinson’s disease with mild cognitive impairment patients
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and mild cognitive impairment (MCI) is a well-established risk factor...
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Zelltod und replikative Seneszenz bei Krebs
Für kontinuierliches Wachstum müssen Krebszellen die Barrieren überwinden, die durch terminale Differenzierung, replikative Seneszenz und Zelltod...