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Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenum
BackgroundCurrently, society and industry generate huge amounts of plastics worldwide. The ubiquity of microplastics is obvious, but its impact on...
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Vitamin C Improves Dasatinib Concentrations Under Hypochlorhydric Conditions of the Simulated Stomach Duodenum Model
PurposepH-dependent drug-drug interactions (DDIs) with poorly soluble, weakly basic drugs may lead to clinical implications. Dasatinib is a tyrosine...
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Transcriptomic responses of rabbits to infections by precocious line and wild-type Eimeria media: revealing molecular signatures and pathway differences in liver and duodenum during the peak and terminal phases of oocyst production
Eimeria media is a principal pathogen responsible for rabbit coccidiosis, targeting the rabbit’s intestinal epithelial cells. This parasitism damages...
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Altered Genome-Wide DNA Methylation in the Duodenum of Common Variable Immunodeficiency Patients
PurposeA large proportion of Common variable immunodeficiency (CVID) patients has duodenal inflammation with increased intraepithelial lymphocytes...
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Global Proteomic Profile Integrated to Quantitative and Morphometric Assessment of Enteric Neurons: Investigation of the Mechanisms Involved in the Toxicity Induced by Acute Fluoride Exposure in the Duodenum
The enteric nervous system is responsible for controlling the gastrointestinal tract (GIT) functions. Enteric neuropathies are highly correlated to...
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The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease
Objective and designCeliac disease (CD) is an intestinal inflammatory disorder of the small intestine. Gliadins are a component of gluten and there...
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Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
Many fatal intoxications have been reported in connection with the consumption of newer, highly potent synthetic cannabinoids. Yet, a possible...
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Untargeted metabolomics of the intestinal tract of DEV-infected ducks
IntroductionDuck enteritis virus (DEV) mainly causes infectious diseases characterized by intestinal haemorrhage, inflammation and parenchymal organ...
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Characterizing interregional differences in the rheological properties and composition of rat small intestinal mucus
The mucus layer in the small intestine is generally regarded as a barrier to drug absorption. However, the mucus layer is a complex system, and...
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A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans
A network of co-hepato/pancreatic stem/progenitors exists in pigs and humans in Brunner’s Glands in the submucosa of the duodenum, in peribiliary...
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Dysfunction of DMT1 and miR-135b in the gut-testis axis in high-fat diet male mice
BackgroundObese patients have been found to be susceptible to iron deficiency, and malabsorption of dietary iron is the cause of obesity-related iron...
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Effects of Three Kinds of Carbohydrate Pharmaceutical Excipients—Fructose, Lactose and Arabic Gum on Intestinal Absorption of Gastrodin through Glucose Transport Pathway in Rats
BackgroundSome glucoside drugs can be transported via intestinal glucose transporters (IGTs), and the presence of carbohydrate excipients in...
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Genetic profile of Chinese patients with small bowel cancer categorized by anatomic location
BackgroundSmall bowel cancer (SBC) is a very rare solid malignancy. Consequently, compared with other malignant gastrointestinal tumors, our...
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Ectonucleotidase Activity in Smooth Muscle Tissues of Rats with a Valproate Model of Autism
Ectonucleotidases play an important role in regulating the level of extracellular nucleotides and nucleosides and are an important part of the...
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Impact of planning organ at risk volume margins and matching method on late gastrointestinal toxicity in moderately hypofractionated IMRT for locally advanced pancreatic ductal adenocarcinoma
BackgroundThis study examined the differences in late gastrointestinal (GI) toxicities in moderately hypofractionated intensity-modulated radiation...
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Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model
Several studies have identified the effects of methamphetamine (MA) on central dopaminergic neurons, but its effects on enteric dopaminergic neurons...
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Investigation of the effect of verapamil on the regional absorption of sofosbuvir from rabbit intestine in situ
PurposeSofosbuvir, a nucleotide antiviral drug, is a Biopharmaceutics Classification System (BCS) class III prodrug suffering from limited intestinal...
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Quantitative sequencing clarifies the role of disruptor taxa, oral microbiota, and strict anaerobes in the human small-intestine microbiome
BackgroundUpper gastrointestinal (GI) disorders and abdominal pain afflict between 12 and 30% of the worldwide population and research suggests these...
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Reduction of dose to duodenum with a refined delineation method of Para-aortic region in patients with locally advanced cervical Cancer receiving prophylactic extended-field radiotherapy
BackgroundTo compare irradiation dose to the second and third portions of duodenum (Duo2 and Duo3) with a new refined and old delineation method of...
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Evaluation of Disorders of Contractile Activity of Smooth Muscle Tissues in 9-Month-Old Rats with a Model of Autism
We studied the effect of carbachol, P 2 receptor agonists, and electric field stimulation on mechanical activity of isolated preparations of the...