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Epidemiology of Plasmodium vivax in Duffy negatives and Duffy positives from community and health centre collections in Ethiopia
BackgroundMalaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 3.8 million cases in 2021 and 61% of the...
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Vivax malaria in Duffy-negative patients shows invariably low asexual parasitaemia: implication towards malaria control in Ethiopia
BackgroundThe increase in detections of Plasmodium vivax infection in Duffy-negative individuals in Africa has challenged the dogma establishing the...
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Association between ABO and Duffy blood types and circulating chemokines and cytokines
Blood group antigens are inherited traits that may play a role in immune and inflammatory processes. We investigated associations between blood...
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Detection of Duffy blood group genotypes and submicroscopic Plasmodium infections using molecular diagnostic assays in febrile malaria patients
BackgroundMalaria remains a severe parasitic disease, posing a significant threat to public health and hindering economic development in sub-Saharan...
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Duffy Blood Group Locus
Duffy protein is expressed on the human erythrocytes acts as receptor for chemokines and malaria parasite, Plasmodium vivax. Duffy receptor protein...
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Chemokines and Chemokine Receptors in Cancer: An Update
The chemokine family is composed of small chemotactic cytokines and receptors that mediate the infiltration of various immune cells. According to the...
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Chemokines in Cancer Therapy
Chemokines are small cell signalling proteins corresponding to family of cytokines that aid in movement of leukocytes. They are low-molecular-weight...
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Plasmodium vivax merozoite-specific thrombospondin-related anonymous protein (PvMTRAP) interacts with human CD36, suggesting a novel ligand–receptor interaction for reticulocyte invasion
BackgroundThe Plasmodium vivax merozoite restrictively invades immature erythrocytes, suggesting that its ligand(s) might interact with...
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Genetic differentiation of Plasmodium vivax duffy binding protein in Ethiopia and comparison with other geographical isolates
BackgroundPlasmodium vivax Duffy binding protein (PvDBP) is a merozoite surface protein located in the micronemes of P. vivax . The invasion of human...
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Human monoclonal antibodies inhibit invasion of transgenic Plasmodium knowlesi expressing Plasmodium vivax Duffy binding protein
BackgroundPlasmodium vivax has been more resistant to various control measures than Plasmodium falciparum malaria because of its greater...
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Differential transmissibility to Anopheles arabiensis of Plasmodium vivax gametocytes in patients with diverse Duffy blood group genotypes
BackgroundMeasuring risk of malaria transmission is complex, especially in case of Plasmodium vivax . This may be overcome using membrane feeding...
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Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India
BackgroundDuffy blood group antigens serve as receptors for Plasmodium vivax invasion into erythrocytes, and they are determined by polymorphisms of...
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Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
BackgroundOver a third of the world’s population is at risk of Plasmodium vivax -induced malaria. The unique aspect of the parasite’s biology and...
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The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes. CXCL8 is...
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Genetic polymorphism and clustering of the Plasmodium cynomolgi Duffy binding protein 1 region II of recent macaque isolates from Peninsular Malaysia
Plasmodium cynomolgi is a simian malaria parasite that has been increasingly infecting humans. It is naturally present in the long-tailed and...
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Sequence analysis of Plasmodium vivax Duffy binding proteins reveals the presence of unique haplotypes and diversifying selection in Ethiopian isolates
BackgroundRed blood cell invasion by the Plasmodium vivax merozoite requires interaction between the Duffy antigen receptor for chemokines (DARC)...
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The biology of unconventional invasion of Duffy-negative reticulocytes by Plasmodium vivax and its implication in malaria epidemiology and public health
Plasmodium vivax has been largely neglected over the past century, despite a widespread recognition of its burden across region where it is endemic....
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Plasmodium knowlesi Duffy binding protein alpha region II (PkDBPαII) in clinical isolates from Peninsular Malaysia and Malaysian Borneo exhibit different immune responses in animal models
Plasmodium knowlesi utilizes the Duffy binding protein alpha (PkDBPα) to facilitate its invasion into human erythrocytes. PkDBPα region II (PkDBPαII)...
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PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial
The receptor-binding domain, region II, of the Plasmodium vivax Duffy binding protein (PvDBPII) binds the Duffy antigen on the reticulocyte surface...
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High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana
BackgroundRecent studies from different malaria-endemic regions including western Africa have now shown that Plasmodium vivax can infect red blood...
