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Features of Ductular Reaction in Rats with Extrahepatic Cholestasis
Ductular reaction develops during liver regeneration, fibrosis, and carcinogenesis. However, the types, stages of formation, and topography of...
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Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration
BackgroundHepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after...
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Role of the Hippo pathway in liver regeneration and repair: recent advances
Although the signaling pathways involved in normal liver regeneration have been well characterized, less has been done for livers affected by chronic...
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3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research
Liver cholestasis is characterized by impairment in bile flow. Among cholestatic diseases, primary biliary cholangitis and primary sclerosing...
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Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis
Cholestasis, the impairment of bile flux out of the liver, is a common complication of many pathological liver disorders, such as cholangiopathies,...
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Therapeutic approaches for cholestatic liver diseases: the role of nitric oxide pathway
Cholestasis describes bile secretion or flow impairment, which is clinically manifested with fatigue, pruritus, and jaundice. Neutrophils play a...
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Noninvasive proteomic biomarkers for alcohol-related liver disease
Alcohol-related liver disease (ALD) is a major cause of liver-related death worldwide, yet understanding of the three key pathological features of...
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Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target
The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial cells that line the bile ducts. Biliary atresia (BA),...
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5-HT2B Receptors in Liver
The liver has many functions, mainly relating to digestion and detoxification, electrolyte/fluid balancing and haemostasis. Hepatic wound healing is...
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Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats
Many heavy metals and metalloids (e.g., Pb, Cd, and Ni) can contaminate the environment and cause severe health problems. Through this study,...
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The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological...
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The Expression of Non B Cell-Derived Immunoglobulins
Although V(D)J recombination and immunoglobulin (Ig) production are traditionally recognised to occur only in B lymphocytes and plasma cells, the...
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The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease
BackgroundIntrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis,...
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Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis
BackgroundUpregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral...
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Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival
BackgroundWhile cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid–base regulation and...
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Liver in infections: a single-cell and spatial transcriptomics perspective
The liver is an immune organ that plays a vital role in the detection, capture, and clearance of pathogens and foreign antigens that invade the human...
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Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis
Chronic exposure to bile acid in the liver due to impaired bile flow induces cholestatic liver disease, resulting in hepatotoxicity and liver...
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Immune-Mediated Liver Disease in the Transplanted Liver
Liver transplantation has evolved as the treatment of choice for many patients with end-stage liver disease. Currently, survival posttransplant is...
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Mouse Models for Diseases in the Cholangiocyte Lineage
Cholangiopathies are an important group of liver diseases affecting the biliary system, and the purpose of this review is to describe how diseases in...
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Neoplastic Diseases
Cancer is a major disease of cats in terms of health and welfare, and skin tumours in cats are the second most common tumour type, accounting for...