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DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis
Renal fibrosis is the final pathological change in renal disease, and aging is closely related to renal fibrosis. Mitochondrial dysfunction has been...
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Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model
Disulfide-bond A oxidoreductase-like protein (DsbA-L) is a molecular chaperone involved in the multimerization of adiponectin. Recent studies have...
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Mitochondrial nucleic acids in innate immunity and beyond
Mitochondria participate in a wide range of cellular processes. One essential function of mitochondria is to be a platform for antiviral signaling...
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Commonality of adherent-invasive Escherichia coli isolated from patients with extraintestinal infections, healthy individuals and the environment
Adherent-invasive Escherichia coli (AIEC) has been implicated as a microbiological factor in inflammatory bowel disease (IBD) pathogenesis. These...
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A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicles
Vaccines against infectious diseases should elicit potent and long-lasting immunity, ideally even in those with age-related decline in immune...
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Reaction of Bifidobacterium longum subsp. infantis Strain ATCC 15697 to Oxidative Stress
The genus Bifidobacterium is one of the most predominant bacterial populations in human-gut microbiota. Despite the increasing number of studies on...
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Novel bacterial proteolytic and metabolic activity associated with dental erosion-induced oral dysbiosis
BackgroundDental erosion is a disease of the oral cavity where acids cause a loss of tooth enamel and is defined as having no bacterial involvement....
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Camelid Single-Domain Antibodies for Targeting Cancer Nanotheranostics
Single-domain antibodies (VHHs), in particular those engineered from the variable heavy-chain fragment (VHH gene) found in Camelidae heavy-chain...
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LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis
Although previous studies have revealed that long noncoding RNAs (lncRNAs) regulate the progression of ischemic acute kidney injury (AKI), the exact...
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Globular adiponectin-mediated vascular remodeling by affecting the secretion of adventitial-derived tumor necrosis factor-α induced by urotensin II
ObjectivesIn this study, we explored how adiponectin mediated urotensin II (UII)-induced tumor necrosis factor-α (TNF-α) and α-smooth muscle actin...
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Evaluation of the prognostic ability of serum uric acid for elderly acute coronary syndrome patients with diabetes mellitus: a prospective cohort study
Objective: This study evaluated the prognostic power of serum uric acid (UA) in predicting adverse events in elderly acute coronary syndrome (ACS)...
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Endocrine Role of Adipose Tissue in Obesity and Related Disorders
Adipose tissue is a complex network of connective tissue constituting many cells types. It is a tissue whose role was assumed to be limited to...
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Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is characterized by glycemia and insulin disorders. Bile acids (BAs) have emerged as vital signaling molecules in...
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Impact of intracellular innate immune receptors on immunometabolism
Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis, oxidative phosphorylation, and metabolite synthesis upon immune cell...
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Expression of the Neuron-Related Genes in hNGF-β-Treated PC12 Cells
Human nerve growth factor-β (hNGF-β) plays a major role in the development and survival of the central and peripheral nervous systems; therefore, it...
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Isolation and characterization of malaria PfHRP2 specific VNAR antibody fragments from immunized shark phage display library
BackgroundMalaria rapid diagnostic tests (RDTs) represent an important antibody based immunoassay platform. Unfortunately, conventional monoclonal...
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Calcium Regulation of Bacterial Virulence
Calcium (Ca2+) is a universal signaling ion, whose major informational role shaped the evolution of signaling pathways, enabling cellular...
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Application of Genetic Engineering in Biotherapeutics Development
PurposeAdvancements in genetic engineering have profoundly impacted the biotherapeutic industry and shaped many of the methods and strategies used...
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Depot-specific effects of treadmill running and rutin on white adipose tissue function in diet-induced obese mice
White adipose tissue (WAT) is a critical organ involved in regulating metabolic homeostasis under obese condition. Strategies that could positively...
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Identification of anti-SF3B1 autoantibody as a diagnostic marker in patients with hepatocellular carcinoma
BackgroundTumor-associated (TA) autoantibodies, which are generated by the immune system upon the recognition of abnormal TA antigens, are promising...
