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A Case of Severe Lead Encephalopathy with Cardiac Arrest Managed During a Chelation Shortage
IntroductionFor many years, the standard of care in the USA has been to treat acute lead encephalopathy with a combination parenteral dimercaprol...
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Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage
The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising...
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Impact of histamine-2 antagonist shortage on the incidence of hypersensitivity reactions to paclitaxel: a reconsideration of premedication protocols in France (PACLIREACT Study)
PurposeAn international shortage of ranitidine led to adjustments in premedication regimens for paclitaxel-based chemotherapy in early October 2019....
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Challenges in Drug Development for Neurological Disorders
Neurological disorders are the group of pathogen, trauma, or disease induced pathologies that mainly affects our central nervous system, impairing...
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AI: Catalyst for Drug Discovery and Development
This abstract explores the multifaceted roles of AI in expediting the drug development process. AI-driven algorithms analyze vast datasets,...
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Prevalence and factors associated with potential drug-drug interactions in prescriptions presented at private pharmacies in Mbarara city, southwestern Uganda
BackgroundDrug-drug interactions (DDIs) influence the effectiveness of medication and thus determine the treatment outcomes of diseases managed with...
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Drug Design Models for Human Diseases by Transgenic Animals
The procedures of drug research and preclinical trials are difficult, and a significant majority of medication candidates are unable to receive...
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Polypharmacology in Old Drug Rediscovery: Drug Repurposing
The concept of drug repurposing has been introduced in this chapter (Sect. 13.8) as a new strategy for MTD drug discovery based on “promising...
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Estimating the impact of label design on reducing the risk of medication errors by applying HEART in drug administration
AbstractMedication errors are one of the biggest problems in healthcare. The medicines’ poor labelling design (i.e. look-alike labels) is a...
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Artificial intelligence for natural product drug discovery
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential...
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Management of donations of personal protective equipment in response to the massive shortage during the COVID-19 health crisis: providing quality equipment to health care workers
BackgroundIn the COVID-19 pandemic context, a massive shortage of personal protective equipment occurred. To increase the available stocks, several...
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Develo** a desktop application for drug-drug interaction checker ordered for chronic diseases in Ethiopian hospitals pharmacy
BackgroundDrug-drug interactions are a major cause of morbidity worldwide and are a leading source of treatment inefficacy. They are classified based...
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FDA Approaches in Monitoring Drug Quality, Forces Impacting the Drug Quality, and Recent Alternative Strategies to Assess Quality in the US Drug Supply
Since the US Food and Drug Administration (FDA) began monitoring the quality of pharmaceutical manufacturing by enforcing current good manufacturing...
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Drug-resistant profiles of extracellular vesicles predict therapeutic response in TNBC patients receiving neoadjuvant chemotherapy
BackgroundPredicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for...
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Exploiting urine-derived induced pluripotent stem cells for advancing precision medicine in cell therapy, disease modeling, and drug testing
The field of regenerative medicine has witnessed remarkable advancements with the emergence of induced pluripotent stem cells (iPSCs) derived from a...
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Costs are a major driver of antibacterial drug prescriptions in Germany: market analysis from 1985 to 2022
In recent years, several threatening developments regarding antibacterial drugs, such as rising bacterial resistance and delivery bottlenecks, have...
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Nanovesicular-Mediated Intranasal Drug Therapy for Neurodegenerative Disease
Numerous neurodegenerative conditions, such as Alzheimer’s, Huntington’s, Parkinson’s, amyotrophic lateral sclerosis, and glioblastoma multiform are...
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Association of statin use with osteoporosis risk: a drug-targeted Mendelian randomization study
BackgroundHypercholesterolemia and the related inflammatory response promote the development of osteoporosis, but whether targeted interventions are...
