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An animal-free preclinical drug screening platform based on human precision-cut kidney slices
ObjectiveRenal fibrosis is one of the main pathophysiological processes underlying the progression of chronic kidney disease and kidney allograft...
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A multiparametric niche-like drug screening platform in acute myeloid leukemia
Functional precision medicine in AML often relies on short-term in vitro drug sensitivity screening (DSS) of primary patient cells in standard...
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Digital Microfluidics with an On-Chip Drug Dispenser for Single or Combinational Drug Screening
Rapid and accurate cancer drug screening is of great importance in precision medicine. However, the limited amount of tumor biopsy samples has...
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AI-Driven Enhancements in Drug Screening and Optimization
The greatest challenge in drug discovery remains the high rate of attrition across the different phases of the process, which cost the industry...
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A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity
Disease, injury and aging induce pathological reactive astrocyte states that contribute to neurodegeneration. Modulating reactive astrocytes...
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An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo
BackgroundRestraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and...
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Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
BackgroundHigh-throughput screening (HTS) of small molecule drug libraries has greatly facilitated the discovery of new cancer drugs. However, most...
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Prostate Cancer Organoids for Tumor Modeling and Drug Screening
Prostate cancer (PCa) is the second most common malignancy and the fifth leading cause of cancer death in men worldwide. Despite its prevalence, the...
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Application of Microfluidics in Drug Development
Microfluidics has become a transformative technology in drug development by offering new solutions that can potentially address some of the...
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A Novel Drosophila-based Drug Repurposing Platform Identified Fingolimod As a Potential Therapeutic for TDP-43 Proteinopathy
Pathogenic changes to TAR DNA-binding protein 43 (TDP-43) leading to alteration of its homeostasis are a common feature shared by several progressive...
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Dried Blood Spots—A Platform for Therapeutic Drug Monitoring (TDM) and Drug/Disease Response Monitoring (DRM)
This review provides an overview on the current applications of dried blood spots (DBS) as matrices for therapeutic drug (TDM) and drug or disease...
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Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers
BackgroundPatient-derived glioma stem-like cells (GSCs) have become the gold-standard in neuro-oncological research; however, it remains to be...
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Screening Non-neutralizing Anti-idiotype Antibodies Against a Drug Candidate for Total Pharmacokinetic and Target Engagement Assay
Non-neutralizing anti-idiotype antibodies against a therapeutic monoclonal antibody (mAb) play a crucial role in the creation of total...
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OrBITS: label-free and time-lapse monitoring of patient derived organoids for advanced drug screening
BackgroundPatient-derived organoids are invaluable for fundamental and translational cancer research and holds great promise for personalized...
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A fluorescence-based assay for Trichomonas vaginalis drug screening
BackgroundThe emergence and spread of drug resistance in Trichomonas vaginalis parasites has become an important concern in trichomoniasis...
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Construction of luciferase-expressing Neospora caninum and drug screening
BackgroundNeospora caninum is an apicomplexan parasite that is particularly responsible for abortions in cattle and neuromuscular disease in dogs....
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An In Silico Platform to Predict Cardiotoxicity Risk of Anti-tumor Drug Combination with hiPSC-CMs Based In Vitro Study
ObjectiveAntineoplastic agent-induced systolic dysfunction is a major reason for interruption of anticancer treatment. Although targeted anticancer...
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Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer
BackgroundPancreatic cancer is one of the most lethal tumors. The aim of this study is to provide an effective therapeutic discovery platform for...
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Zebrafish Model for Drug Discovery and Screening
The zebrafish as a preclinical drug development model is discussed considering different aspects. 3-Rs Replacement, Reduction and Refinement related...
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Drug Screening Assays on Medulloblastoma Stem Cells Using Compound Libraries
Conventional chemotherapies for medulloblastoma are restricted to only proliferative population leaving the cancer stem cells unscathed. This...