Search
Search Results
-
Virtual Screening Process: A Guide in Modern Drug Designing
Due to its capacity to drastically cut the cost and time necessary for experimental screening of compounds, virtual screening (VS) has grown to be a...
-
AI-Driven Enhancements in Drug Screening and Optimization
The greatest challenge in drug discovery remains the high rate of attrition across the different phases of the process, which cost the industry...
-
Digital Microfluidics with an On-Chip Drug Dispenser for Single or Combinational Drug Screening
Rapid and accurate cancer drug screening is of great importance in precision medicine. However, the limited amount of tumor biopsy samples has...
-
Prostate Cancer Organoids for Tumor Modeling and Drug Screening
Prostate cancer (PCa) is the second most common malignancy and the fifth leading cause of cancer death in men worldwide. Despite its prevalence, the...
-
DrugRep: an automatic virtual screening server for drug repurposing
Computationally identifying new targets for existing drugs has drawn much attention in drug repurposing due to its advantages over de novo drugs,...
-
Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes
Selective chemical inhibitors are critical for reaction phenoty** to identify drug-metabolizing enzymes that are involved in the elimination of...
-
Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers
BackgroundPatient-derived glioma stem-like cells (GSCs) have become the gold-standard in neuro-oncological research; however, it remains to be...
-
A fluorescence-based assay for Trichomonas vaginalis drug screening
BackgroundThe emergence and spread of drug resistance in Trichomonas vaginalis parasites has become an important concern in trichomoniasis...
-
Construction of luciferase-expressing Neospora caninum and drug screening
BackgroundNeospora caninum is an apicomplexan parasite that is particularly responsible for abortions in cattle and neuromuscular disease in dogs....
-
Application of Microfluidics in Drug Development
Microfluidics has become a transformative technology in drug development by offering new solutions that can potentially address some of the...
-
Zebrafish Model for Drug Discovery and Screening
The zebrafish as a preclinical drug development model is discussed considering different aspects. 3-Rs Replacement, Reduction and Refinement related...
-
Cytopathic Effect (CPE )-Based Drug Screening Assay for SARS-CoV-2
Identification of an effective antiviral for the treatment of COVID-19 is considered one of the holy grails in the bid to end the pandemic. However,...
-
Pharmacological Screening: Drug Discovery
Traditionally, new treatments have been discovered through random testing of natural products, primarily parts/extracts of plants and herbs, on...
-
A multiparametric niche-like drug screening platform in acute myeloid leukemia
Functional precision medicine in AML often relies on short-term in vitro drug sensitivity screening (DSS) of primary patient cells in standard...
-
OrBITS: label-free and time-lapse monitoring of patient derived organoids for advanced drug screening
BackgroundPatient-derived organoids are invaluable for fundamental and translational cancer research and holds great promise for personalized...
-
Zebrafish Model for Neurotoxic Drug Screening: Methodologies and Protocols
Zebrafish is one of the emerging animal models for drug screening. A neuronal system similar to humans makes zebrafish a potential candidate as an...
-
An animal-free preclinical drug screening platform based on human precision-cut kidney slices
ObjectiveRenal fibrosis is one of the main pathophysiological processes underlying the progression of chronic kidney disease and kidney allograft...
-
Computational Drug Discovery and Design
This second edition provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput...
-
Drug Screening Assays on Medulloblastoma Stem Cells Using Compound Libraries
Conventional chemotherapies for medulloblastoma are restricted to only proliferative population leaving the cancer stem cells unscathed. This...
-
Drug Target Elucidation Through Isolation and Analysis of Drug-Resistant Mutants in Cryptococcus neoformans
Drug target identification is an essential component to antifungal drug development. Many methods, including large chemical library screening,...