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The imidazoline I2 receptor agonist 2-BFI reduces abuse-related effects of morphine: self-administration and drug discrimination
RationaleIncreasing evidence shows that imidazoline I 2 receptor agonists enhance opioid-induced analgesia, suggesting that the combination of I 2 ...
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Drug Addiction and Drug Dependency
Drug abuse and dependency liability assessments are important components of the discovery, development, and evaluation of novel drug entities and are...
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Assessment of Temperature-Dependent Drug Release of Solubilizing Nanoformulations Using the SITUA
The evaluation of temperature-dependent drug release for solubilizing nanoformulations uses a modification of the stable isotope ultrafiltration...
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Impact of Apparatus and Adapter on In vitro Drug Release of Ophthalmic Semisolid Drug Products
PurposeIn vitro release testing (IVRT) is a widely used tool for evaluating the quality and performance of drug products. However, standardized...
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Understanding the stimulus effects of nicotine and bupropion in a drug-drug discriminated goal-tracking task
RationaleBupropion is a non-nicotine medication for smoking cessation that has overlap** stimulus effects with nicotine as demonstrated in drug...
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The use of therapeutic drug monitoring to highlight an over-looked drug-drug interaction leading to imatinib treatment failure
BackgroundChronic oral anticancer therapies, are increasingly prescribed and present new challenges including the enhanced risk of overlooked...
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Multiplexed discrimination of SARS-CoV-2 variants via plasmonic-enhanced fluorescence in a portable and automated device
Portable assays for the rapid identification of lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to aid...
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Role of Genomics and Proteomics in Drug Discovery
Genomics and proteomics are two powerful technologies that are revolutionizing the drug discovery process. Genomics is the study of the entire genome...
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Impact of Genetic Variation on Drug Response
Pharmacogenomics investigates the influence of genetics on drug response, with the ultimate aim of giving patients the right drug at the right dose...
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A neuromarker for drug and food craving distinguishes drug users from non-users
Craving is a core feature of substance use disorders. It is a strong predictor of substance use and relapse and is linked to overeating, gambling,...
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Multivariate Analysis of Solubility Parameters for Drug-Polymer Miscibility Assessment in Preparing Raloxifene Hydrochloride Amorphous Solid Dispersions
The success of obtaining solid dispersions for solubility improvement invariably depends on the miscibility of the drug and polymeric carriers. This...
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Computer Aided Drug Design
Various challenges such as cost and time consumption problems associated with traditional drug design and development process have been overcome with...
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Addressing Breast Cancer Disparities in Advancements for Conquering Drug Resistance
Breast cancer is a global concern with high morbidity and mortality rates. While incidence rates remain high in developed countries compared to...
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Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues
RationaleWhen people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include...
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Toward a New Drug Policy Agreement
This chapter is divided into five sections. The first one describes the beginnings and evolution of the international drug control system. The second...
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Extended Drug Access and Escalation of Drug Self-Administration
In this chapter we first describe the intravenous drug self-administration technique in rats, with a focus on cocaine. Where relevant, we also...
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Polypharmacology: New Paradigms in Drug Development
Polypharmacology is the term coined for the interaction of drug molecules with multiple targets and is responsible for the side effects and...
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Modelling Based Approaches to Support Generic Drug Regulatory Submissions-Practical Considerations and Case Studies
Model informed drug development (MiDD) is useful to predict in vivo exposure of drugs during various stages of the drug development process. This...
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Drug-Excipient Compatibility Study Through a Novel Vial-in-Vial Experimental Setup: A Benchmark Study
Drug-excipient compatibility study (DECS) is one of the critical steps during pre-formulation studies to select the appropriate excipient to obtain a...
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Use of the Same Model or Modeling Strategy Across Multiple Submissions: Focus on Complex Drug Products
Evidence shows that there is an increasing use of modeling and simulation to support product development and approval for complex generic drug...
