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Common hyper-entropy patterns identified in nicotine smoking, marijuana use, and alcohol use based on uni-drug dependence cohorts
Substance use disorders present similar behaviors and psychopathologies related to impaired decision making/inhibition control and information...
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The Dependence of the Electrophysiological Effects of Class III Antiarrhythmic Drug Refralon on the Frequency of Myocardium Activation
We studied the frequency dependence of the effects of the novel Russian class III antiarrhythmic drug refralon on the duration of action potentials...
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Generative models for age, race/ethnicity, and disease state dependence of physiological determinants of drug dosing
Dosing requires consideration of diverse patient-specific factors affecting drug pharmacokinetics and pharmacodynamics. The available pharmacometric...
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Drug Absorption
Drug absorption involves the movement of drug molecules from the site of absorption to systemic circulation and is a prerequisite to observe a...
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Drug Release
Drug release from dosage forms (also termed drug liberation) is a prerequisite for absorption to occur: only free molecules in solution can cross...
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In vitro studies on the dependence of drug deposition in dentin on drug concentration, contact time, and the physicochemical properties of the drugs
The chemical analysis of dental hard tissues can provide information on previous drug use due to the deposition of drugs into this tissue. For the...
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Drug-Drug and Food-Drug Interactions of Pharmacokinetic Nature
The most relevant pharmacokinetic mechanisms of drug-drug (DD) and food-drug (FD) interactions are summarized from a perspective that will allow the...
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Drug Excretion
Drug excretion involves processes responsible for physically removing a drug from the body, either unchanged or in the form of biotransformation...
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Drug Addiction and Drug Dependency
Drug abuse and dependency liability assessments are important components of the discovery, development, and evaluation of novel drug entities and are...
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Drug Dependence and Abuse
Physical dependence and addiction differ in that addiction causes activation of certain dopaminergic pathways in the mesolimbic system. Addiction...
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Cancer Drug Resistance and Metabolic Reprogramming
There is a complex and strong association between metabolic reprogramming and the phenomenon of drug resistance in cancer. Cancer cell metabolic...
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Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence
BackgroundClinical and preclinical research have demonstrated that short-term exposure to nicotine during the initial experimentation stage can lead...
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Opioid Dependence, Tolerance, and Withdrawal
This chapter describes the main adaptive changes occurring after repeated opioid administration at different levels: behavioral, pharmacological,...
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Laplace Transform Based Modeling of Drug Delivery with Reversible Drug Binding in a Multilayer Tissue
ObjectiveDrug delivery from a drug-loaded device into an adjacent tissue is a complicated process involving drug transport through diffusion and...
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Applications of Molecular Dynamics Simulations in Drug Discovery
In the current drug development process, molecular dynamics (MD) simulations have proven to be very useful. This chapter provides an overview of the...
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Anhedonia in Nicotine Dependence
Prior findings indicate that trait anhedonia enhances the likelihood of becoming a tobacco smoker, and preliminary evidence suggests that smoking...
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Fierce poison to others: the phenomenon of bacterial dependence on antibiotics
Beyond the development of resistance, the effects of antibiotics on bacteria and microbial communities are complex and far from exhaustively studied....
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Drug Properties
Drug discoveryDrug discovery remains a complex and iterative process accompanied with a high failure rate. Before compounds enter the clinic,...
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Repurposing of Drug: Utility of Animal Models
Drug repurposing is an up-and-coming concept in the world of medicine. It is an efficient way to use already existing drug formulations in the...
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Dependence of Bioavailability on Mean Absorption Time: What Does It Tell Us?
The extent and rate of bioavailability are fundamental measures to characterize the pharmacokinetics of drugs after oral administration. Together...
