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DNA methylation may partly explain psychotropic drug-induced metabolic side effects: results from a prospective 1-month observational study
BackgroundMetabolic side effects of psychotropic medications are a major drawback to patients’ successful treatment. Using an epigenome-wide...
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Pulmonary Side Effects of Immunotherapy
The effectiveness of drugs known as immune checkpoint inhibitors in the treatment of cancer is increasingly well understood. The use of immunotherapy...
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Ferroptotic therapy in cancer: benefits, side effects, and risks
Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane...
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Gastrointestinal Side Effects of Anticancer Therapy
Cancer treatments have been key to improve survivorship of patients affected by this dreadful disease. Among these, cytotoxic chemotherapy and, in...
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CBD-oil as a potential solution in case of severe tamoxifen-related side effects
Tamoxifen may lead to bothersome side effects contributing to non-compliance and decreased quality of life. Patients searching for relief are...
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Schizophrenia, Curcumin and Minimizing Side Effects of Antipsychotic Drugs: Possible Mechanisms
Schizophrenia is a mental disorder characterized by episodes of psychosis; major symptoms include hallucinations, delusions, and disorganized...
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Polypharmacology in Predicting Drug Toxicity: Drug Promiscuity
Drug promiscuity refers to multitarget activity of a drug and can elicit two distinct or opposing actions: adverse side effects and improved...
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Drug Absorption
Drug absorption involves the movement of drug molecules from the site of absorption to systemic circulation and is a prerequisite to observe a...
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Effects of drug-drug interactions and CYP3A4 variants on alectinib metabolism
In this study, the effects of 17 CYP3A4 variants and drug-drug interactions (DDI) with its mechanism on alectinib metabolism were investigated. In...
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Drug-Drug and Food-Drug Interactions of Pharmacokinetic Nature
The most relevant pharmacokinetic mechanisms of drug-drug (DD) and food-drug (FD) interactions are summarized from a perspective that will allow the...
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Side Effects of Central Analgesic Drugs
Strong opioid analgesics, such as morphine, are the most widely used, centrally acting class of analgesics that are available in the clinic for the...
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Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats
In this study, we investigated the effects of grape seed proanthocyanidin extract (GSPE) against the side effects of high-dose administration of...
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Reinforcing effects of fentanyl analogs found in illicit drug markets
RationaleThe potent synthetic opioid fentanyl, and its analogs, continue to drive opioid-related overdoses. Although the pharmacology of fentanyl is...
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Microfluidic Technologies for Precise Drug Delivery
There is a current demand for new and more sophisticated drug delivery systems (DDSs) to efficiently deliver therapeutics to the desired tissues,...
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Side effects of low-dose tamoxifen: results from a six-armed randomised controlled trial in healthy women
BackgroundAdherence to adjuvant tamoxifen therapy is suboptimal, and acceptance of tamoxifen for primary prevention is poor. Published results...
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Introduction to Drug Resistance in Cancer
Treating cancer has so many hurdles, and drug resistance is one of them. Treatment strategies are evolving for cancer due to innate and acquired...
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Drug Delivery Strategies in Parkinson’s Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting around ten million people worldwide. PD is an age-related...
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Innovative Drug Delivery Systems for Drug-Resistant Breast Cancer
Breast cancer is the most common and one of the deadliest cancers affecting women worldwide. The mainstay treatment for breast cancer is surgery and...
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Side effect prediction based on drug-induced gene expression profiles and random forest with iterative feature selection
One in every ten drug candidates fail in clinical trials mainly due to efficacy and safety related issues, despite in-depth preclinical testing. Even...
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Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
Hydrogels that provide mechanical support and sustainably release therapeutics have been used to treat tendon injuries. However, most hydrogels are...
