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Metabotropic glutamate group II receptor activation in the ventrolateral dorsal striatum suppresses incentive motivation for cocaine in rats
RationaleAfter a history of intermittent cocaine intake, rats develop patterns of drug use characteristic of substance use disorder. The dorsal...
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Association between iron accumulation in the dorsal striatum and compulsive drinking in alcohol use disorder
RationaleBrain iron accumulation has been observed in neuropsychiatric disorders and shown to be related to neurodegeneration.
Objectives ...
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p-Nrf2/HO-1 Pathway Involved in Methamphetamine-induced Executive Dysfunction through Endoplasmic Reticulum Stress and Apoptosis in the Dorsal Striatum
Methamphetamine (METH) abuse is known to cause executive dysfunction. However, the molecular mechanism underlying METH induced executive dysfunction...
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Texture analysis of dorsal striatum in functional neurological (conversion) disorder
In this study, it was aimed to evaluate the dorsal striatum nuclei of patients diagnosed with Functional Neurological Disorder by texture analysis...
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Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice
Dysfunction of striatal dopaminergic circuits has been implicated in motor impairment and Parkinson’s disease (PD)-related circadian perturbations...
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Cilia in the Striatum Mediate Timing-Dependent Functions
Almost all brain cells contain cilia, antennae-like microtubule-based organelles. Yet, the significance of cilia, once considered vestigial...
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Differential Influence of Amyloid-β on the Kinetics of Dopamine Release in the Dorsal and Ventral Striatum of Rats
Dopaminergic dysfunction is a part of Alzheimer’s disease pathology. The brain accumulation of amyloid-β of toxic form is a key link of the...
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On the learning of addictive behavior: Sensation-seeking propensity predicts dopamine turnover in dorsal striatum
We asked if sensation-seeking is linked to premorbid personality characteristics in patients with addictive disorders, or the characteristics follow...
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The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior
The secondary motor cortex (M2) encodes choice-related information and plays an important role in cue-guided actions. M2 neurons innervate the dorsal...
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Alternative Approaches to Understanding Habit Learning in the Dorsolateral Striatum
Our daily lives are full of habits. Yet, even though we know them intimately, habits are surprisingly hard to pin down in laboratory settings in...
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The Role of the Striatum in Motor Learning
The role of the striatum in motor learning is addressed. Modern molecular genetic approaches have made it possible to take a closer look at the...
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Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and ΔFosB in the striatum brain area of rats
Morphine is among the most powerful analgesics and pain-relieving agents. However, its addictive properties limit their medical use because patients...
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Oleoylethanolamide attenuates cocaine-primed reinstatement and alters dopaminergic gene expression in the striatum
The lipid oleoylethanolamide (OEA) has been shown to affect reward-related behavior. However, there is limited experimental evidence about the...
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Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor
Selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, are frequently combined with medical psychostimulants such as methylphenidate...
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Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning
The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference...
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The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour
RationaleAdenosine A 2A receptors (A 2A R) in the dorsal striatum have been implicated in goal-directed behaviour. While activation of these receptors...
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Dissociating the contributions of sensorimotor striatum to automatic and visually guided motor sequences
The ability to sequence movements in response to new task demands enables rich and adaptive behavior. However, such flexibility is computationally...
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Orbitofrontal cortex control of striatum leads economic decision-making
Animals must continually evaluate stimuli in their environment to decide which opportunities to pursue, and in many cases these decisions can be...
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The Role of the Striatum in Organizing Voluntary Behavior
The striatopallidal system is a key structure in the regulation of motor behavior [Bazyan et al., 2011], though the mechanisms and specific features...