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Therapeutic Applications of Dopamine D3 Receptor Function New Insight After 30 Years Of Research
The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Functionreviews the state of the knowledge on the dopamine D3 receptor and its role...
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Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs
The role of the striatum in motor control is commonly assumed to be mediated by the two striatal efferent pathways characterized by striatal...
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Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons
Elevated dopamine transmission in psychosis is assumed to unbalance striatal output through D1- and D2-receptor-expressing spiny-projection neurons...
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Dopamine increases risky choice while D2 blockade shortens decision time
Dopamine is crucially involved in decision-making and overstimulation within dopaminergic pathways can lead to impulsive behaviour, including a...
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Facial mimicry is not modulated by dopamine D2/3 and opioid receptor antagonism
RationaleAccording to theories of embodied cognition, facial mimicry — the spontaneous, low-intensity imitation of a perceived emotional facial...
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Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
RationaleThe nucleus accumbens (NAc) core gates motivationally relevant behavioral action sequences through afferents from cortical and subcortical...
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Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons
Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation of pain. As chronic pain conditions are associated...
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Differential Roles of the D1- and D2-Like Dopamine Receptors Within the Ventral Tegmental Area in Modulating the Antinociception Induced by Forced Swim Stress in the Rat
Several preclinical and clinical studies indicate that exposure to acute stress may decrease pain perception and increases pain tolerance. This...
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Progressive Degeneration and Adaptive Excitability in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons Exposed to HIV-1 Tat and Morphine
The striatum is especially vulnerable to HIV-1 infection, with medium spiny neurons (MSNs) exhibiting marked synaptodendritic damage that can be...
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Dopamine Receptor Supersensitivity and Schizophrenia
Despite decades of clinical and preclinical research, the etiopathology of schizophrenia remains unknown. One of the most long-standing theories...
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Intestinal Dopamine Receptor D2 is Required for Neuroprotection Against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Dopaminergic Neurodegeneration
A wealth of evidence has suggested that gastrointestinal dysfunction is associated with the onset and progression of Parkinson’s disease (PD)....
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Long-Lived Dopamine D2-Receptor Supersensitivity: Neurotoxicity in the Presence and Absence of Neuronal Damage
Overt destruction of a nerve by a highly selective neurotoxin produces an accompanying loss of function. However, the abnormality of nerve loss is...
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Exogenous growth hormone administration during total sleep deprivation changed the microRNA-9 and dopamine D2 receptor expressions followed by improvement in the hippocampal synaptic potential, spatial cognition, and inflammation in rats
RationaleDisorders caused by total sleep deprivation can be modulated by the administration of growth hormone, which could affect the expression of...
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Long-Lived Dopamine D2-Receptor Supersensitivity: Neurotoxicity in the Presence and Absence of Neuronal Damage
Overt destruction of a nerve by a highly selective neurotoxin produces an accompanying loss of function. However, the abnormality of nerve loss is...
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Cerebellar dopamine D2 receptors regulate social behaviors
The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also contributes to higher cognitive functions including...
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A Historical Perspective on the Dopamine D3 Receptor
Before 1990, the multiplicity of dopamine receptors beyond D1 and D2 had remained a controversial concept, despite its substantial clinical...
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High Fat Diet Increases [3H] Flunitrazepam Binding in the Mouse Brain that is Dependent on the Expression of the Dopamine D2 Gene
Dopamine is an important neuromodulator in the brain that binds to dopamine D1-like receptors (D1, D5) as well as dopamine D2-like receptors (D2, D3,...
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Effects of the atypical antipsychotic and D3/D2 dopamine partial agonist cariprazine on effort-based choice behavior: implications for modeling avolition
RationaleCariprazine is an atypical antipsychotic that acts as a D3/D2 receptor partial agonist. In addition to treating positive symptoms of...
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In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition
Pathophysiological changes in dopamine neurons precede their demise and contribute to the early phases of Parkinson’s disease (PD). Intracellular...
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Initial characterization of a transgenic mouse with overexpression of the human D1-dopamine receptor in the heart
Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase...
