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From words to phrases: neural basis of social event semantic composition
Events are typically composed of at least actions and entities. Both actions and entities have been shown to be represented by neural structures...
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Joubert syndrome causing mutation in C2 domain of CC2D2A affects structural integrity of cilia and cellular signaling molecules
Cilia are organelles extend from cells to sense external signals for tuning intracellular signaling for optimal cellular functioning. They have...
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BANKSY unifies cell ty** and tissue domain segmentation for scalable spatial omics data analysis
Spatial omics data are clustered to define both cell types and tissue domains. We present Building Aggregates with a Neighborhood Kernel and Spatial...
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COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition
Newborns can acquire immunological protection to SARS-CoV-2 through vaccine-conferred antibodies in human breast milk. However, there are some...
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A current perspective on snake venom composition and constituent protein families
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey subjugation. With modern proteomics there has been a rapid expansion...
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Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns
BackgroundFollowing exposure to traumatic stress, women are twice as likely as men to develop mood disorders. Yet, individual responses to such...
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Role of Gut Microbiome Composition in Sha** Host Immune System Development and Health
The gut microbiome is a community of commensal microbes in the gastrointestinal tract that are ecologically, physiologically, and symbiotically...
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Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease
The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin, SorCS1, SorCS2 and SorCS3. While their physiological roles...
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Distinct changes in endosomal composition promote NLRP3 inflammasome activation
Inflammasome complexes are pivotal in the innate immune response. The NLR family pyrin domain containing protein 3 (NLRP3) inflammasome is activated...
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The effects of chemotherapy on resting energy expenditure, body composition, and cancer-related fatigue in women with breast cancer: a prospective cohort study
BackgroundBreast cancer (BC) is the most prevalent tumor in women. Improvements in treatment led to declined mortality, resulting in more survivors...
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Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study
BackgroundBreast density (BD) is a strong risk factor for breast cancer. Little is known about how BD develops during puberty. Understanding BD...
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Exploring breast tissue microbial composition and the association with breast cancer risk factors
BackgroundMicrobial dysbiosis has emerged as an important element in the development and progression of various cancers, including breast cancer....
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Role of C-terminal domain of Mycobacterium tuberculosis PE6 (Rv0335c) protein in host mitochondrial stress and macrophage apoptosis
PE/PPE proteins of Mycobacterium tuberculosis (Mtb) target the host organelles to dictate the outcome of infection. This study investigated the...
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Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition
Polycomb group proteins have a critical role in silencing transcription during development. It is commonly proposed that Polycomb-dependent changes...
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Novel genome-wide DNA methylation profiling reveals distinct epigenetic landscape, prognostic model and cellular composition of early-stage lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD) has been a leading cause of cancer-related mortality worldwide. Early intervention can significantly improve...
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Type IIx muscle fibers are related to poor body composition, glycemic and lipidemic blood profiles in young females: the protective role of type I and IIa muscle fibers
PurposeThe aim of the present study was to investigate the association between muscle fiber composition, body composition, resting glycemic–lipidemic...
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Modeling of Transmembrane Domain and Full-Length TLRs in Membrane Models
Toll-like receptors (TLRs), classified as pattern recognition receptors, have a primordial role in the activation of the innate immunityInnate...
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Structure Composition and Intracellular Transport of Clathrin-Mediated Intestinal Transmembrane Tight Junction Protein
Tight junctions (TJs) are located in the apical region of the junctions between epithelial cells and are widely found in organs such as the brain,...
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Fluorescence Sensing of Physical Parameters and Chemical Composition in Gases and Condensed Media
Versatility of fluorescence sensing extends to different gas, liquid and solid media. Probing these media of different chemical composition and...
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Analysis of the Specificity of Auto-Reactive Antibodies to Individual Fragments of the Extracellular Domain of Desmoglein 3 in Patients with Pemphigus Vulgaris
A method for the analysis of the epitope specificity of auto-reactive antibodies to desmoglein 3 (Dsg3) using competitive ELISA has been developed....