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Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU
BackgroundChemotherapy is a primary treatment for cancer, but its efficacy is often limited by cancer-associated bacteria (CAB) that impair tumor...
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Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines
BackgroundStudies of molecular mechanisms underlying tumor cell signaling highlighted a critical role for kinases in carcinogenesis and cancer...
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DnaK Chaperone Takes Part in Folding but Not in Refolding of Thermal Inactivated Proteins in Bacillus subtilis
AbstractThe role of the DnaKJE and Trigger Factor (TF) chaperones in folding and refolding of proteins in Bacillus subtilis is studied. Bacterial...
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A review on oligomeric polydispersity and oligomers-dependent holding chaperone activity of the small heat-shock protein IbpB of Escherichia coli
Inclusion body–associated proteins IbpA and IbpB of MW 16 KDa are the two small heat-shock proteins (sHSPs) of Escherichia coli , and they have only...
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White yam (Dioscorea rotundata) plants exhibiting virus-like symptoms are co-infected with a new potyvirus and a new crinivirus in Ethiopia
White yam ( Dioscorea rotundata ) plants collected from farmers’ fields and planted at the Areka Agricultural Research Center, Southern Ethiopia,...
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Heat shock proteins and the biogenesis of cellular membranes
The successful function of cells is importantly contributed by lipid membranes that are more than a simple physical barrier. The major components of...
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Psychrophilic Pseudomonas helmanticensis proteome under simulated cold stress
Himalayan mountains are distinctly characterized for their unique climatic and topographic variations; therefore, unraveling the cold-adaptive...
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Molecular Chaperones as Therapeutic Target: Hallmark of Neurodegenerative Disorders
Misfolded and aggregated proteins build up in neurodegenerative illnesses, which causes neuronal dysfunction and ultimately neuronal death. In the...
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3-Hydroxykynurenine as a Potential Ligand for Hsp70 Proteins and Its Effects on Drosophila Memory After Heat Shock
Kynurenine products of tryptophan metabolism are modifiers of the nervous activity and oxidative processes in mammals and invertebrates....
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A molecular docking study between heavy metals and hydrophilic Hsp70 protein to explore binding pockets
Microorganisms are abundant in whole biosphere and exert influential activities on numerous biological phenomena. The source of heavy metal...
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Protein quality control: from molecular mechanisms to therapeutic intervention—EMBO workshop, May 21–26 2023, Srebreno, Croatia
Protein quality control pathways ensure a functional proteome and rely on a complex proteostasis network (PN) that is composed of molecular...
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Multivalent protein–protein interactions are pivotal regulators of eukaryotic Hsp70 complexes
Heat shock protein 70 (Hsp70) is a molecular chaperone and central regulator of protein homeostasis (proteostasis). Paramount to this role is Hsp70’s...
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Functional Significance of Mycolicibacterium smegmatis Toxin–Antitoxin Module in Resistance to Antibiotics and Oxidative Stress
AbstractToxin–antitoxin systems are widespread in bacteria, including pathogens such as Mycobacterium tuberculosis . The possible functions of the...
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Proteomic Biomarkers: What They Are and How Type 2 Diabetes Mellitus Has Similarities with Other Diseases
Type 2 diabetes mellitus (T2DM) is the most frequent form of diabetes, characterized by insulin resistance and impaired insulin release. Its...
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A genome-wide screening of the 70 kDa heat shock protein (HSP70) genes in the rotifer Brachionus plicatilis sensu stricto with a characterization of two heat-inducible HSP70 genes
The 70 kDa heat shock proteins (HSP70s) and the constitutive members of the HSP70 family (heat shock cognates; HSC70s) play essential roles in...
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Polymorphism of Core and Symbiotically Specialized Genes in the Polytypic Species of Nodule Bacteria
AbstractThe polytypic species of nodule bacteria Rhizobium leguminosarum (includes biovars viciae and trifolii ) and Neorhizobium galegae (biovars orientalis...
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Genomic loss of the HSP70cA gene in the vertebrate lineage
Metazoan 70 kDa heat shock protein (HSP70) genes have been classified into four lineages: cytosolic A ( HSP70cA ), cytosolic B ( HSP70cB ), endoplasmic...
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Recombinant production of ESAT-6 antigen in thermoinducible Escherichia coli: the role of culture scale and temperature on metabolic response, expression of chaperones, and architecture of inclusion bodies
The heat-inducible expression system has been widely used to produce recombinant proteins in Escherichia coli . However, the rise in temperature...
