We are improving our search experience. To check which content you have full access to, or for advanced search, go back to the old search.

Search

Please fill in this field.
Filters applied:
Biomedicine

Search Results

Showing 1-20 of 10,000 results

  1. A new method for multiancestry polygenic prediction improves performance across diverse populations

    Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal performance in non-European populations raise concerns about...

    Haoyu Zhang, Jianan Zhan, ... Nilanjan Chatterjee in Nature Genetics
    Article 25 September 2023

  2. Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

    Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges remain to be addressed before PRSs can be implemented in...

    Niall J. Lennon, Leah C. Kottyan, ... Eimear E. Kenny in Nature Medicine
    Article Open access 19 February 2024

  3. Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations

    Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ...

    Dong**g Liu, Dara Meyer, ... Alexander W. Charney in Nature Genetics
    Article Open access 13 March 2023

  4. Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations

    Trace Amine Associated Receptor 1 (TAAR1) is a novel pharmaceutical target under investigation for the treatment of several neuropsychiatric...

    Britto Shajan, Shashikanth Marri, ... Pramod C. Nair in Human Genomics
    Article Open access 11 June 2024

  7. Characterization of the Illumina EPIC array for optimal applications in epigenetic research targeting diverse human populations

    The Illumina EPIC array is widely used for high-throughput profiling of DNA cytosine modifications in human samples, covering more than 850,000...

    Zhou Zhang, Chang Zeng, Wei Zhang in Epigenetics Communications
    Article Open access 01 December 2022

  9. Improving polygenic prediction in ancestrally diverse populations

    Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) have been...

    Yunfeng Ruan, Yen-Feng Lin, ... Tian Ge in Nature Genetics
    Article 05 May 2022

  11. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

    We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which...

    Catherine Tcheandjieu, **ang Zhu, ... Themistocles L. Assimes in Nature Medicine
    Article 01 August 2022

  13. Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

    Background

    Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts...

    Tian Ge, Marguerite R. Irvin, ... Elizabeth W. Karlson in Genome Medicine
    Article Open access 29 June 2022

  14. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

    We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and...

    Anubha Mahajan, Cassandra N. Spracklen, ... Andrew P. Morris in Nature Genetics
    Article 12 May 2022

  15. Characterization of the immunoglobulin lambda chain locus from diverse populations reveals extensive genetic variation

    Immunoglobulins (IGs), crucial components of the adaptive immune system, are encoded by three genomic loci. However, the complexity of the IG loci...

    William S. Gibson, Oscar L. Rodriguez, ... Corey T. Watson in Genes & Immunity
    Article 21 December 2022

  16. Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

    Background

    Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining...

    Stefanie H. Mueller, Alvina G. Lai, ... Karoline B. Kuchenbaecker in Genome Medicine
    Article Open access 26 January 2023

  18. Calibrated prediction intervals for polygenic scores across diverse contexts

    Polygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide range of fields. We show that PGS performance varies...

    Kangcheng Hou, Ziqi Xu, ... Bogdan Pasaniuc in Nature Genetics
    Article 17 June 2024

  19. Principles and methods for transferring polygenic risk scores across global populations

    Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait or disease and may become a valuable tool for advancing...

    Linda Kachuri, Nilanjan Chatterjee, ... Tian Ge in Nature Reviews Genetics
    Article 24 August 2023

  20. Implementing genomic screening in diverse populations

    Background

    Population-based genomic screening has the predicted ability to reduce morbidity and mortality associated with medically actionable...

    Noura S. Abul-Husn, Emily R. Soper, ... Eimear E. Kenny in Genome Medicine
    Article Open access 05 February 2021
Did you find what you were looking for? Share feedback.