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Genetic Associations with Coronavirus Susceptibility and Disease Severity
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) global public health...
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Association of disease severity and genetic variation during primary Respiratory Syncytial Virus infections
BackgroundRespiratory Syncytial Virus (RSV) disease in young children ranges from mild cold symptoms to severe symptoms that require hospitalization...
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Predicting the Disease Severity of Virus Infection
The COVID-19 pandemic has resulted in unprecedented burden on global health and economic systems, promoting worldwide efforts to understand, control,...
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Synaptic loss and its association with symptom severity in Parkinson’s disease
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments....
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Plasma oligomer beta-amyloid is associated with disease severity and cerebral amyloid deposition in Alzheimer’s disease spectrum
BackgroundMultimer detection system-oligomeric amyloid-β (MDS-OAβ) is a measure of plasma OAβ, which is associated with Alzheimer’s disease (AD)...
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Accelerated immune ageing is associated with COVID-19 disease severity
BackgroundThe striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the...
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Association of women-specific health factors in the severity of Parkinson’s disease
Parkinson’s disease (PD) is an age-related neurological disorder known for the observational differences in its risk, progression, and severity...
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Classification of Parkinson’s disease severity using gait stance signals in a spatiotemporal deep learning classifier
AbstractParkinson’s disease (PD) is a degenerative nervous system disorder involving motor disturbances. Motor alterations affect the gait according...
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A nationwide cohort study on diabetes severity and risk of Parkinson disease
There is growing evidence that patients with type 2 diabetes mellitus (DM) have an increased risk of develo** Parkinson’s disease (PD) and share...
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Cytokines and lymphocyte subsets are associated with disease severity of severe fever with thrombocytopenia syndrome
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome...
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Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer’s disease
Dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), and Parkinson’s disease (PD) collectively known as Lewy body diseases (LBDs) are...
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Smaller Cerebellar Lobule VIIb is Associated with Tremor Severity in Parkinson’s Disease
Alterations in the cerebellum’s morphology in Parkinson’s disease (PD) point to its pathophysiological involvement in this movement disorder. Such...
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Plasma metabolites of aromatic amino acids associate with clinical severity and gut microbiota of Parkinson’s disease
Gut microbial proteolytic metabolism has been reportedly altered in Parkinson’s disease (PD). However, the circulating aromatic amino acids (AAA)...
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Severity in the genomic age: the significance of lived experience to understandings of severity
This article explores the significance of lived experience to understandings of severity in the genomic age. It draws upon data from structured...
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Horizontal Vestibulo-Ocular Reflex Deficit as a Biomarker for Clinical Disease Onset, Severity, and Progression of Machado-Joseph Disease
Because of the crucial importance of finding a useful biomarker for further clinical trials in Machado-Joseph disease (MJD), and based on our...
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Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity
BackgroundInteractions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link...
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Co-administration of probiotics and vitamin D reduced disease severity and complications in patients with Parkinson’s disease: a randomized controlled clinical trial
RationaleProbiotics have beneficial effects on the nervous system by modulating the gut-brain axis. Additionally, vitamin D supplementation presents...
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Clinical characteristics and factors affecting disease severity in hospitalized tick-borne encephalitis patients in Norway from 2018 to 2022
PurposeTo describe the clinical characteristics and factors associated with disease severity in a Norwegian cohort of hospitalized patients with...
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Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination
Bruton’s tyrosine kinase (BTK) is an emerging target in multiple sclerosis (MS). Alongside its role in B cell receptor signaling and B cell...
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Quantitative susceptibility map** from basal ganglia and related structures: correlation with disease severity in progressive supranuclear palsy
ObjectiveWe examined whether mean magnetic susceptibility values from deep gray matter structures in patients with progressive supranuclear palsy...
