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Disease modification in inflammatory skin disorders: opportunities and challenges
Progress in understanding of the mechanisms underlying chronic inflammatory skin disorders, such as atopic dermatitis and psoriasis vulgaris, has led...
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Comparative efficacy of surgical approaches to disease modification in Parkinson disease
Parkinson’s disease (PD) may optimally be treated with a disease-modifying therapy to slow progression. We compare data underlying surgical...
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ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against several chronic diseases....
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Prodromal Parkinson's disease: hype or hope for disease-modification trials?
The ultimate goal in Parkinson's disease (PD) research remains the identification of treatments that are capable of slowing or even halting the...
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Lactylation: the novel histone modification influence on gene expression, protein function, and disease
Lactic acid, traditionally considered as a metabolic waste product arising from glycolysis, has undergone a resurgence in scientific interest since...
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In vivo and ex vivo gene therapy for neurodegenerative diseases: a promise for disease modification
Neurodegenerative diseases (NDDs), including AD, PD, HD, and ALS, represent a growing public health concern linked to aging and lifestyle factors,...
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Emerging role of protein modification in inflammatory bowel disease
The onset of inflammatory bowel disease (IBD) involves many factors, including environmental parameters, microorganisms, and the immune system....
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Complicated Role of Post-translational Modification and Protease-Cleaved Fragments of Tau in Alzheimer’s Disease and Other Tauopathies
Tau, a microtubule-associated protein predominantly localized in neuronal axons, plays a crucial role in promoting microtubule assembly, stabilizing...
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Nucleic acid and protein methylation modification in renal diseases
Although great efforts have been made to elucidate the pathological mechanisms of renal diseases and potential prevention and treatment targets that...
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New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignancy, presenting a formidable challenge to the medical community owing to its...
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Targeted genome-modification tools and their advanced applications in crop breeding
Crop improvement by genome editing involves the targeted alteration of genes to improve plant traits, such as stress tolerance, disease resistance or...
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Oligonucleotide therapeutics and their chemical modification strategies for clinical applications
BackgroundOligonucleotide therapeutics have emerged as a promising and dynamic class of pharmaceutical agents with remarkable potential for treating...
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The role of N-methyladenosine modification in acute and chronic kidney diseases
N 6-methyladenosine (m6A) modification is a kind of RNA modification in which methylation occurs at the sixth N position in adenosine in RNA, which...
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RNA modification: mechanisms and therapeutic targets
RNA modifications are dynamic and reversible chemical modifications on substrate RNA that are regulated by specific modifying enzymes. They play...
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Disease Modification in Epilepsy: Behavioural Accompaniments
According to the definition of epileptogenesis, “disease modification” refers to every clinically relevant therapeutic outcome which does not...
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Nutraceuticals for Alzheimer's Disease: A Promising Therapeutic Approach
This book reviews the potential effect of diet modification, lipids, and carbohydrate consumptions, vitamin supplementation, antioxidants, and...
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Histone modification in podocyte injury of diabetic nephropathy
Diabetic nephropathy (DN), an important complication of diabetic microvascular disease, is one of the leading causes of end-stage renal disease...
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Emerging role of RNA modification and long noncoding RNA interaction in cancer
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression...
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Survey of attitude to human genome modification in Nigeria
Gene editing and mitochondrial replacement therapy (MRT) are biotechnologies used to modify the host nuclear and mitochondrial DNA, respectively....
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Epigenetic Modification in Aluminum-Induced Neurotoxicity
The toxicity of aluminum has been confirmed from many aspects, such as plant, animal, model organism, in vitro study, and epidemiological studies....