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Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
RationaleEmerging evidence indicates that persistent alcohol consumption escalates psychosocial trauma achieved by social defeat stress (SDS)-induced...
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Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice
BackgroundCholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we...
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Diosgenin, a steroidal sapogenin, arrests arthritis through modulation of inflammatory cytokines and oxidative stress biomarkers in Wistar rats
Diosgenin (DGN) is a well-known steroidal sapogenin that is obtained from the hydrolysis of dioscin. The current research aimed to explore the...
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Diosgenin potentiates the anticancer effect of doxorubicin and volasertib via regulating polo-like kinase 1 and triggering apoptosis in hepatocellular carcinoma cells
A common approach to cancer therapy is the combination of a natural product with chemotherapy to overcome sustained cell proliferation and...
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Neuroprotective role of Diosgenin, a NGF stimulator, against Aβ (1–42) induced neurotoxicity in animal model of Alzheimer’s disease
Diosgenin is a neurosteroid derived from the plants and has been previously reported for its numerous health beneficial properties, such as...
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Intrathecal Infusion of Diosgenin during the Chronic Phase of Spinal Cord Injury Ameliorates Motor Function and Axonal Density
AbstractThe chronic phase of spinal cord injury (SCI) is the most challenging to treat. The extension of disrupted axons is necessary for prominent...
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Diosgenin Inhibits Excessive Proliferation and Inflammatory Response of Synovial Fibroblasts in Rheumatoid Arthritis by Targeting PDE3B
Rheumatoid arthritis (RA) is a chronic inflammation that can lead to loss of range of joint abnormalities in severe cases. Diosgenin has...
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Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts
Several studies have suggested that some kind of Dioscorea species (yam) or yam-contained herbal medicines have cognitive enhancement effect....
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Diosgenin as a Novel Alternative Therapy for Inhibition of Growth, Invasion, and Angiogenesis Abilities of Different Glioblastoma Cell Lines
Fenugreek ( Trigonella foenum - graecum ) seeds and roots of wild yam ( Dioscorea villosa ) possess nutritional and medicinal properties and have been used...
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Diosgenin-loaded niosome as an effective phytochemical nanocarrier: physicochemical characterization, loading efficiency, and cytotoxicity assay
BackgroundThe use of phytochemicals to prevent or suppress tumours is known as chemoprevention. Numerous plant-derived agents have been reported to...
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The convergent application of metabolites from Avena sativa and gut microbiota to ameliorate non-alcoholic fatty liver disease: a network pharmacology study
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a serious public health issue globally, currently, the treatment of NAFLD lies still in the...
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Plant-Based Bioactive Compounds in Cancer Therapeutics
Cancer is a dreadful disease, and it is considered as one of the biggest health problems for the human populations and demands an intense strategy to...
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Selectivity and potency of natural product PIM kinase inhibitors identified by in silico docking
PIM3 (Proviral Integration site for Maloney murine leukemia virus kinase 3) is a proto-oncogene with serine/threonine kinase activity that prevents...
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Species of the Genus Polygonatum found in the Western Himalayas
Polygonatum cirrhifolium, Polygonatum multiflorum, and Polygonatum verticillatum are significant medicinal herbs of Himalayas belonging to the genus...
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Water-Soluble Arginyl–Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS
Microglia-mediated neuroinflammatory responses are well known to inhibit neurogenesis in the dentate gyrus (DG) of the adult hippocampus, and growing...
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Navigating Skin Delivery Horizon: An Innovative Approach in Pioneering Surface Modification of Ultradeformable Vesicles
In the dynamic landscape of pharmaceutical advancements, the strategic application of active pharmaceutical ingredients to the skin through topical...
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Multifaceted Molecular Targets of Anti-Inflammatory Agents from Ayurvedic Plants
The relationship between prolonged inflammation and the occurrence of different fatal diseases like cancer was first identified in the nineteenth...
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Revisiting the ethnomedicinal, ethnopharmacological, phytoconstituents and phytoremediation of the plant Solanum viarum Dunal
Solanum viarum , a perennial shrub, belongs to the family Solanaceae known for its therapeutic value worldwide. As a beneficial remedial plant, it is...
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Therapeutic Phytoconstituents-I
Phytoconstituents are compounds present in plants which performs various functions to protect plant’s vitality. Besides awarding tremendous benefits...
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Network pharmacology in combination with bibliometrics analysis on the mechanism of compound Kushen injection in the treatment of radiation pneumonia and lung cancer
Radiation pneumonia is a common adverse reaction during radiotherapy in lung cancer patients, which negatively impacts the quality of life and...
