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Digestive enzyme supplementation in prescription drugs, over-the-counter drugs, and enzyme foods
BackgroundDigestive enzyme supplements are used in various fields, including prescription drugs, over-the-counter drugs, and enzyme foods, but few...
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Development and evaluation of a digestive formulation using a microbial enzyme for treatment of dyspepsia
PurposeA digestive enzyme is prepared as a treatment for dyspepsia by aiding in the breakdown of food, and its representative ingredient is porcine...
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Prognostic value of CSN5 in patients with digestive system cancers: a systematic review and meta-analysis
BackgroundDespite the understanding of the COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on its value to...
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The effect of physical stability and modified gastrointestinal tract behaviour of resveratrol-loaded NLCs encapsulated alginate beads
Nanostructured lipid carriers (NLC) have low storage and gastrointestinal stability, limiting their applicability. The work aimed to elevate the...
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The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis
BackgroundIn recent years, the Fibrinogen to pre-albumin ratio (FPR) has been reported in many studies to be significantly associated with the...
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Revitalizing allicin for cancer therapy: advances in formulation strategies to enhance bioavailability, stability, and clinical efficacy
The main objective of this review is to highlight the therapeutic potential of allicin, a defense molecule in garlic known for its diverse health...
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The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1
BackgroundGallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1)...
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Stability and integrity of self-assembled bovine parvovirus virus‑like particles (BPV‑VLPs) of VP2 and combination of VP1VP2 assisted by baculovirus-insect cell expression: a potential logistical platform for vaccine deployment
BackgroundBovine parvovirus (BPV) is an autonomous DNA virus with a smaller molecular size and subtle differences in its structural proteins, unlike...
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UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability
BackgroundRenal interstitial fibrosis is a common pathway for the progressive development of chronic renal diseases (CKD) with different etiology,...
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Nanoemulsions Containing Megestrol Acetate: Development, Characterization, and Stability Evaluation
Many active pharmaceutical ingredients (API) are poorly soluble in water and their low oral bioavailability is a major hindrance to their potential...
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Antioxidant Potential of Probiotics and Postbiotics: A Biotechnological Approach to Improving Their Stability
AbstractToday there is an increasing amount of scientific evidence of the effects of probiotic bacteria as components of the gut microbiota on human...
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Dissociation mechanics and stability of type A botulinum neurotoxin complex by means of biophysical evaluation
PurposeBiophysical characterisation of type A botulinum neurotoxin (BoNT/A) could be challenging since it exists in association with neurotoxin...
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Oxidative Stability in Lipid Formulations: a Review of the Mechanisms, Drivers, and Inhibitors of Oxidation
The importance of lipid-based formulations in addressing solubility and ultimately the bioavailability issues of the emerging drug entities is...
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m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway
BackgroundGemcitabine resistance has brought great challenges to the treatment of pancreatic cancer. The N6-methyladenosine (m6A) mutation has been...
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Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer
BackgroundThe incidence of colorectal cancer (CRC) has increased in recent years. Identification of accurate tumor markers has become the focus of...
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Gut bacterial consortium enriched in a biofloc system protects shrimp against Vibrio parahaemolyticus infection
BackgroundShrimp cultured in a biofloc system (BFS) have a lower disease incidence than those farmed in a water exchange system (WES). Although a...
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Stability of levothyroxine tablets in blister packaging versus bottles and vials under simulated in-use conditions
IntroductionLevothyroxine, the standard-of-care treatment for hypothyroidism, is susceptible to degradation when exposed to light and moisture and is...
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miR-590-5p/Tiam1-mediated glucose metabolism promotes malignant evolution of pancreatic cancer by regulating SLC2A3 stability
BackgroundT lymphoma invasion and metastasis 1 (Tiam1) is a tumor related gene that specifically activates Rho-like GTPases Rac1 and plays a critical...
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Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability
Lutein has been used as a dietary supplement for the treatment of eye diseases, especially age-related macular degeneration. For oral formulations,...
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Food Vacuole as a Drug Target
During the intraerythrocytic stage, the parasite multiplies and utilizes 60–80% of the hemoglobin within 24 h. The parasite moves through various...