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Reproductive experience alters the effects of diazepam and fluoxetine on anxiety-like behaviour, fear extinction, and corticosterone levels in female rats
OverviewReproductive experience (pregnancy and motherhood) leads to long-term changes in the neurobiological and hormonal features of anxiety in rats...
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Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)
Benzodiazepines are widely administered drugs to treat anxiety and insomnia. In addition to tolerance development and abuse liability, their chronic...
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Effects of Acute Swimming Stress on the Behavioral and Neurochemical Effects of Pyrazolo[C]pyridine Derivative GIZh-72 and Diazepam in BALB/c and C57BL/6 Mice
The effects of acute swimming stress (ASS) on the behavioral and neurochemical actions of a pyrazolo[C]pyridine derivative GIZh-72 (20 mg/kg, i.p.)...
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Glycyrrhizae Radix suppresses lipopolysaccharide- and diazepam-induced nerve inflammation in the hippocampus, and contracts the duration of pentobarbital- induced loss of righting reflex in a mouse model
Nerve inflammation is linked to the development of various neurological disorders. This study aimed to examine whether Glycyrrhizae Radix effectively...
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Sexually dimorphic effects of prenatal diazepam exposure on respiratory control and the monoaminergic system of neonate and young rats
Pregnancy is highly affected by anxiety disorders, which may be treated with benzodiazepines, especially diazepam (DZP), that can cross the placental...
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Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam
Tetramethylenedisulfotetramine (TETS), a noncompetitive GABA A receptor antagonist, is a potent, highly lethal convulsant that is considered to be a...
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Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital
Neuroinflammation is associated with the development of hypoactive delirium, which results in poor clinical outcomes. Drugs effective against...
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The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study
BackgroundTramadol is a widely used synthetic opioid. Substantial research has previously focused on the neurological effects of this drug, while the...
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Stability of Diazepam Solution for Injection Following Long-Term Storage in an Ambient Temperature of the Mediterranean Climate
PurposeDiazepam is utilized as a convulsion antidote following nerve gas attacks. As an emergency medicine, it requires storage at ambient...
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Design and In Vitro Evaluation of Intranasal Diazepam for Treating Acute Repetitive Seizures: a Technical Note
This study aimed to develop and characterize a novel microemulsion-based intranasal diazepam for treating acute repetitive seizures (ARS). The...
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Nose-to-Brain Delivery of Diazepam from an Intranasal Aqua-Triggered In-Situ (ATIS) Gelling Microemulsion: Monitoring Brain Uptake by Microdialysis
Background and ObjectivesAn innovative intranasal aqua-triggered in-situ (ATIS) gel is a polymer-free in-situ gelling microemulsion which gels...
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Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People
Background and ObjectivesDriving under the influence of diazepam is increasing in China. The pharmacokinetics of diazepam and its metabolites,...
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Comparison of Different Liquid and Semisolid Vehicles Selected for Oral Administration of Pellets and Minitablets with Diazepam: In Vitro Investigation
The acceptability and palatability of a dosage form are extremely important to improve patient compliance. Mixing oral solid dosage forms with food...
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Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
Status epilepticus (SE), a serious and often life-threatening medical emergency, is characterized by abnormally prolonged seizures. It is not...
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Intentional Hydroxychloroquine Overdose Treated with High-Dose Diazepam: an Increasing Concern in the COVID-19 Pandemic
IntroductionRecent attention on the possible use of hydroxychloroquine and chloroquine to treat COVID-19 disease has potentially triggered a number...
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Diazepam and ethanol differently modulate neuronal activity in organotypic cortical cultures
BackgroundThe pharmacodynamic results of diazepam and ethanol administration are similar, in that each can mediate amnestic and sedative-hypnotic...
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Comparative Study of Sorption Phenomena Between Three Medications and Syringes Made of Cyclic Olefin Copolymer or Polypropylene
IntroductionMedical syringes are widely used in hospitals to store and administer drugs, and the contact time between the drugs and these syringes...
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Inpatient GHB withdrawal management in an inner-city hospital in Sydney, Australia: a retrospective medical record review
RationaleRegular consumption of gamma-hydroxybutyrate (GHB) may result in a dependence syndrome that can lead to withdrawal symptoms. There are...
