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Diabetic and Nephropathy
Recently, several genes that predispose to type 2 diabetes have been discovered. There is ample evidence to indicate a genetic predisposition to the...
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Insights into the Therapeutic Potential of Phytoconstituents as an Epigenetic Modulators in Diabetic Nephropathy
Chronic diabetes is commonly associated with the development of nephropathy, which is a prevalent complication. Hyperglycemia is believed to initiate...
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Evaluation of chicory leaf extract on chronic kidney disease model in streptozotocin-induced diabetic nephropathy
This study aimed to evaluate Chicory leaf extract for its potential activity on CKD model in STZ induced diabetic nephropathy in Wistar albino rats....
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Identification of miRNA-Target Gene-Transcription Factor Regulatory Network as Functional Motifs Involved in Glomerular Diabetic Nephropathy
AbstractThe gene regulatory approach based on retrieving information from the database provides a detailed characterization of the molecular...
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Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression
BackgroundDiabetic nephropathy (DN) is a major complication of diabetes mellitus. Clinical reports indicate that smoking is a significant risk factor...
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Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy
Diabetic nephropathy (DN) is a common diabetic complication. Studies show that mitophagy inhibition induced-ferroptosis plays a crucial role in DN...
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Title: Bioinformatic Identification of Genes Involved in Diabetic Nephropathy Fibrosis and their Clinical Relevance
Tubulointerstitial fibrosis is an important pathological feature of diabetic nephropathy that is associated with impaired renal function. However,...
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Dysregulation of miR-25-3p in Diabetic Nephropathy and Its Role in Inflammatory Response
To investigate the expression level of miR-25-3p in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), and its effect on...
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Roflumilast ameliorates diabetic nephropathy in rats through down-regulation of JAK/STAT signaling pathway
Roflumilast is a potent selective inhibitor of the phosphodiesterase-4 enzyme which greatly manifest an anti-inflammatory activity in chronic...
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Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy
Glomerular mesangial cell proliferation and extracellular matrix accumulation contribute to the progression of diabetic nephropathy (DN). As a...
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Wogonin upregulates SOCS3 to alleviate the injury in Diabetic Nephropathy by inhibiting TLR4-mediated JAK/STAT/AIM2 signaling pathway
BackgroundDiabetic nephropathy (DN) is a life-threatening renal disease and needs urgent therapies. Wogonin is renoprotective in DN. This study aimed...
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Histone modification in podocyte injury of diabetic nephropathy
Diabetic nephropathy (DN), an important complication of diabetic microvascular disease, is one of the leading causes of end-stage renal disease...
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Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy
BackgroundDiabetic nephropathy (DN) is the leading cause of end-stage renal disease, and histopathologic glomerular lesions are among the earliest...
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Identification of co-expressed central genes and transcription factors in acute myocardial infarction and diabetic nephropathy
BackgroundAcute myocardial infarction (AMI) and diabetic nephropathy (DN) are common clinical co-morbidities, but they are challenging to manage and...
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Tanshinone IIA is superior to paricalcitol in ameliorating tubulointerstitial fibrosis through regulation of VDR/Wnt/β-catenin pathway in rats with diabetic nephropathy
Glomerulosclerosis and tubulointerstitial fibrosis (TIF) are closely involved in the development of diabetic nephropathy (DN). Moreover, the...
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miRNA signatures in diabetic retinopathy and nephropathy: delineating underlying mechanisms
A worldwide failure to achieve glycemic targets has led to complications associated with diabetes mellitus. In addition to genetic and other risk...
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Biomarkers of Diabetes-Induced Nephropathy
Diabetic nephropathy (DN) is the leading cause of end stage renal disease. Therefore, the assessment of renal function and early diagnosis of...
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The effect of a methylxanthine vasodilator: pentoxifylline on the treatment of diabetic nephropathy—a meta-analysis
This meta-analysis aimed to comprehensively evaluate the efficacy and safety of pentoxifylline (PTF) in the treatment of diabetic nephropathy (DN)...
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Artificial intelligence assists identification and pathologic classification of glomerular lesions in patients with diabetic nephropathy
BackgroundGlomerular lesions are the main injuries of diabetic nephropathy (DN) and are used as a crucial index for pathologic classification. Manual...
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Ulinastatin ameliorated streptozotocin-induced diabetic nephropathy: Potential effects via modulating the components of gut-kidney axis and restoring mitochondrial homeostasis
Growing evidence supports the role of the gut-kidney axis and persistent mitochondrial dysfunction in the pathogenesis of diabetic nephropathy (DN)....
