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Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation
Activated microglia play an important role in driving photoreceptor degeneration-associated neuroinflammation in the retina. Controlling...
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Developmental Dynamics of the Functional State of the Retina in Mice with Inherited Photoreceptor Degeneration
The standard model system for studies of inherited retinal pathologies consists of C3H mice, which have a mutation in the Pde6b gene. These animals...
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Role of VLC-PUFAs in Retinal and Macular Degeneration
Very-long-chain polyunsaturated fatty acids (VLC-PUFAs) are a special class of fatty acids that are present in the retina and a few other human...
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Cerebellar Developmental Disorders and Cerebellar Nuclei
While significant progress has been made in the last 10 years in understanding the development of cerebellar nuclei, they remain a relatively less...
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The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration
Early investigations of the neuronal actin filament cytoskeleton gave rise to the notion that, although growth cones exhibit high levels of actin...
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Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration
In neurons, RNA granules are transported along the axon for local translation away from the soma. Recent studies indicate that some of this transport...
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Sex-dependent variation in cartilage adaptation: from degeneration to regeneration
Despite acknowledgement in the scientific community of sex-based differences in cartilage biology, the implications for study design remain unclear,...
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Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision
Photoreceptors (PRs), as the most abundant and light-sensing cells of the neuroretina, are responsible for converting light into electrical signals...
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Neuroprotective effects of GSK-343 in an in vivo model of MPTP-induced nigrostriatal degeneration
Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal neurons, which causes disabling motor disorders....
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Intervertebral disc degeneration and inflammatory microenvironment: expression, pathology, and therapeutic strategies
BackgroundIntervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP), posing a significant socioeconomic burden. Recent studies...
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Selective vulnerability of motor neuron types and functional groups to degeneration in amyotrophic lateral sclerosis: review of the neurobiological mechanisms and functional correlates
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterised by a progressive loss of motor neurons controlling voluntary...
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Developmental Disorders of the Cerebellum and Neurotrophic Factors
The cerebellum plays a central role in motor control and cognition features such as attention. Thus, a disturbance in cerebellar development results...
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Development and Developmental Disorders of the Human Cerebellum
The cerebellum is one of the best studied parts of the brain. The cerebellar cortex is composed of four main types of neurons: granule cells,...
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Development and Developmental Disorders of the Forebrain
The forebrain comprises those structures that are derived from the most rostral part of the neural plate, i.e. the primary prosencephalon. The...
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The Ubiquitin–Proteasome System and Cerebellar Developmental Disease
A variety of developmental diseases of the cerebellum are associated with the dysregulation of proteins regulated by the ubiquitin–proteasome system...
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Development and Developmental Disorders of the Spinal Cord
Even after its development is complete, the spinal cord remains a rather simple structure with a ventral motor horn, a dorsal sensory horn and an...
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Abnormal Innervation, Demyelination, and Degeneration of Spiral Ganglion Neurons as Well as Disruption of Heminodes are Involved in the Onset of Deafness in Cx26 Null Mice
GJB2 gene mutations are the most common causes of autosomal recessive non-syndromic hereditary deafness. For individuals suffering from severe to...
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Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
Adult neurotoxicity (ANT) and developmental neurotoxicity (DNT) assessments aim to understand the adverse effects and underlying mechanisms of...
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Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis
The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a transmembrane heme exporter essential for embryonic vascular development. However,...
