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Effect of Long-Term Reduction of Deuterium Content in the Body on Hemoglobin Production and Parameters of Erythropoiesis
Anemia is the most widespread hematological disease, therefore the search for new approaches to erythropoiesis regulation in the body remains an...
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Deuterium in drug discovery: progress, opportunities and challenges
Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one neutron to a molecule. Despite being a subtle change,...
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Changes in Secretion of the Thyroid and Pituitary Glands with a Gradual Decrease in Deuterium Body Content
We studied changes in the secretion of thyroid hormones and pituitary thyroid-stimulating hormone (TSH) in young mature male Wistar rats during...
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Reactive Alterations in Thymic Lymphocytopoiesis to Short-Term Decrease in Deuterium Content in the Body
We studied changes in thymic lymphocytopoiesis induced by a short-term decrease in deuterium content in the body. The experiment was performed on...
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Stable Isotope Tracer Methods for the Measure of Skeletal Muscle Protein Turnover
In this chapter, we will discuss two approaches to measure protein metabolism using stable isotope tracers and the advantages and disadvantages of...
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Impact of Reduced Deuterium Intake on Thermoregulation
The role of stable hydrogen isotopes in the thermoregulation and its regulation is poorly studied. We analyzed fluctuations in body temperature and...
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Improved Pharmacokinetic and Pharmacodynamic Profile of Deuterium-Reinforced Tricyclic Antidepressants Doxepin, Dosulepin, and Clomipramine in Animal Models
Background and ObjectivesDoxepin, dosulepin, and clomipramine are tricyclic antidepressants (TCAs) that act as serotonin and noradrenaline reuptake...
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Stable isotope applications in drug development and the elucidation of mechanisms of drug metabolism
Over the last 50 years, advances in the production of stable isotopes and mass spectrometry instrumentation have fueled elucidation of endogenous...
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Response of Pituitary—Thyroid Axis to a Short-Term Shift in Deuterium Content in the Body
We studied functional changes in rat pituitary—thyroid axis after a short-term shift in deuterium body content. Male Wistar rats consumed...
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Advancements in Pulsed Stable Isotope-Resolved Metabolomics
The understanding of biochemical processes of metabolism is gained through the measurement of the concentration of intermediates and the rate of...
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Deuterium Oxide Enhances Expression of the ada, alkA, and luxA Genes of Escherichia coli Induced by Methyl Methanesulfonate
AbstractWe have studied the expression of the E. coli ada and alk A genes and the lux A lux-operon gene in the plasmid and under the control of the alk ...
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Chemical Isotope Labeling LC-MS for Metabolomics
Due to the great diversity of chemical and physical properties of metabolites as well as a wide range of concentrations of metabolites present in...
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Effect of Buffer Salts on Physical Stability of Lyophilized and Spray-Dried Protein Formulations Containing Bovine Serum Albumin and Trehalose
This study examined the effect of buffer salts on the physical stability of spray-dried and lyophilized formulations of a model protein, bovine serum...
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Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How tumours use nutrients and the relative rates of...
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Synergistic Effects of Heavy Water in Health Prospects
This chapter provides an insight into heavy water/deuterium use in the medicinal chemistry and biotechnology, due to its physicochemical...
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Neuroprotective Effects of Deuterium-Depleted Water (DDW) Against H2O2-Induced Oxidative Stress in Differentiated PC12 Cells Through the PI3K/Akt Signaling Pathway
Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease....
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Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma
BackgroundDiffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often...
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Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model
Rationale( R,S )-ketamine, an N -methyl-D-aspartate receptor (NMDAR) antagonist, exhibits rapid and long-lasting antidepressant effects and...
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CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease
BackgroundEfavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to...
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Mechanism of Insoluble Aggregate Formation in a Reconstituted Solution of Spray-Dried Protein Powder
BackgroundSpray-drying is considered a promising alternative drying method to lyophilization (freeze-drying) for therapeutic proteins. Particle...
