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A Novel Thermal-driven Self-assembly Method to Prepare Albumin Nanoparticles: Formation Kinetics, Degradation Behavior and Formation Mechanism
Nanoparticles based on bovine serum albumin (BSA), which shares 76% homology with human serum albumin (HSA), have emerged as a promising candidate...
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Influence of Crystal Disorder on the Forced Oxidative Degradation of Vortioxetine HBr
The present study investigates the impact of the solid-state disorder of vortioxetine hydrobromide (HBr) on oxidative degradation under accelerated...
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Degradation kinetics of artesunate for the development of an ex-tempore intravenous injection
BackgroundArtesunate is recommended by the World Health Organization (WHO) for parenteral treatment of severe Plasmodium falciparum malaria....
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Kinetics of Synaptic Current
Current kinetics takes into account three key components of receptor function. They include an open or activated state, a deactivated state, and a...
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Extracellular targeted protein degradation: an emerging modality for drug discovery
Targeted protein degradation (TPD) has emerged in the past decade as a major new drug modality to remove intracellular proteins with bispecific small...
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LC–MS Characterization and Stability Assessment Elucidate Correlation Between Charge Variant Composition and Degradation of Monoclonal Antibody Therapeutics
Aggregation stability of monoclonal antibody (mAb) therapeutics is influenced by many critical quality attributes (CQA) such as charge and...
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Photocatalytic Degradation of Dyes in Wastewater Using Solar Enhanced Nickel Oxide (NiO) Nanocatalysts Prepared by Chemical Methods
This study examined the surface morphology and photocatalytic activity of nickel oxide (NiO) nanoparticles prepared through a chemical method. The...
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A Rapid 3-Day Excipient Screening Methodology and its Application in Identifying Chemical Stabilizers for Solid Formulations with Mixed Mechanisms of Degradation
This study outlines a practical approach for assessing chemical instability by heating the drug-excipient binary mixtures or multi-excipient...
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A phenomenological model of pulsatile blood pressure-affected degradation of polylactic acid (PLA) vascular stent
The stent implantation may alter the post-operative patient’s blood pressure, and bioresorbable vascular stents (BVS) as a candidate to treat...
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EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma
Epithelial membrane protein 3 (EMP3) is an N -glycosylated tetraspanin with a putative trafficking function. It is highly expressed in isocitrate...
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Effect of Structurally Related Compounds on Desupersaturation Kinetics of Indomethacin
PurposeThe pharmaceutical literature contains examples wherein desupersaturation from high concentrations does not proceed to equilibrium...
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Pharmacodynamics of Cyclin D1 Degradation in Ovarian Cancer Xenografts with Repeated Oral SHetA2 Dosing
SHetA2 is a promising, orally active small molecule with anticancer properties that target heat shock proteins. In this study, we aimed to...
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Thermal degradation of Affinisol HPMC: Optimum Processing Temperatures for Hot Melt Extrusion and 3D Printing
PurposeAffinisol HPMC HME is a new popular form of hypromellose specifically designed for the hot melt extrusion and 3D printing of pharmaceutical...
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Heat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer
BackgroundNME1 has been exploited as a potential translational target for decades. Substantial efforts have been made to upregulate the expression of...
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Exploring Muscarinic Acetylcholine Receptor Binding Kinetics with Fluorescence Anisotropy
Many different assays are available for measuring ligand binding to muscarinic acetylcholine receptors. Each has advantages and throwbacks, making...
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Kinetics of the Growth of Enterococcus spp. Biofilm Formed by Strains Isolated from Patients with Infectious Complications after Large joint Replacements
We studied the kinetics of growth of biofilms and plankton forms of Enterococcus spp . strains isolated in implant-associated infection of large...
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PROTACs: Current Trends in Protein Degradation by Proteolysis-Targeting Chimeras
In the recent past, proteolysis-targeting chimera (PROTAC) technology has received enormous attention for its ability to overcome the limitations of...
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In vitro degradation and erosion behavior of commercial PLGAs used for controlled drug delivery
Copolymers of lactic (or lactide) and glycolic (or glycolide) acids (PLGAs) are among the most commonly used materials in biomedical applications,...
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Numerical Methods for Modeling Enzyme Kinetics
Differential equations are used to describe time-dependent changes in enzyme kinetics and pharmacokinetics. Analytical and numerical methods can be...
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Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells
The endoplasmic reticulum is a key site for protein production and quality control. More than one-third of proteins are synthesized and folded into...