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Molecular mechanism of vimentin nuclear localization associated with the migration and invasion of daughter cells derived from polyploid giant cancer cells
BackgroundPolyploid giant cancer cells (PGCCs), a specific type of cancer stem cells (CSCs), can be induced by hypoxic microenvironments, chemical...
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Subthalamic nucleus deep brain stimulation alleviates oxidative stress via mitophagy in Parkinson’s disease
Subthalamic nucleus deep brain stimulation (STN-DBS) has the potential to delay Parkinson’s disease (PD) progression. Whether oxidative stress...
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The plant-like protein phosphatase PPKL regulates parasite replication and morphology in Toxoplasma gondii
BackgroundThe protozoan parasite Toxoplasma gondii encodes dozens of phosphatases, among which a plant-like phosphatase absent from mammalian...
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Towards a neurocognitive profile in familial cerebral cavernous malformations
BackgroundFamilial cerebral cavernous malformations (FCCM) is a rare autosomal dominant disease, characterized by vascular malformations that can...
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Phosphorylation of keratin 18 serine 52 regulates mother–daughter centriole engagement and microtubule nucleation by cell cycle-dependent accumulation at the centriole
Serine-52 (Ser52) is the major physiologic site of keratin 18 (K18) phosphorylation. Here, we report that serine-52 phosphorylated K18 (phospho-Ser52...
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Indirect neurogenesis in space and time
During central nervous system (CNS) development, neural progenitor cells (NPCs) generate neurons and glia in two different ways. In direct...
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Myosins in the Nucleus
Although originally characterized as a cytoplasmic protein, myosin of various classes also performs key functions in the nucleus. We review the data...
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Generation of Polyploid Giant Cancer Cells (PGCCs) from Hey Ovarian Cancer Cells and Analysis of Embryonic Properties
Polyploid giant cancer cells (PGCCs) play a fundamental role in tumor initiation, dormancy, drug resistance, and metastasis, although the detailed...
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Dynamic chromosome association with nuclear organelles in living cells
The development of progressively sophisticated tools complemented by the integration of live cell imaging enhances our understanding of the...
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Development of the livestock pathogen Trypanosoma (Nannomonas) simiae in the tsetse fly with description of putative sexual stages from the proboscis
BackgroundTsetse-transmitted African animal trypanosomiasis is recognised as an important disease of ruminant livestock in sub-Saharan Africa, but...
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Role of syntaxin3 an apical polarity protein in poorly polarized keratinocytes: regulation of asymmetric barrier formations in the skin epidermis
The skin epidermis exhibits an asymmetric structure composed of multilayered keratinocytes and those in the outer layers form two-way physical...
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Mesencephalon m1/m2
Two important structures of the visual/oculomotor system originate from this neuromere, the superior colliculus, and the oculomotor nucleus/nerve...
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Germ plasm and the origin of the primordial germ cells in the oriental river prawn Macrobrachium nipponense
Germ plasm is a special cytoplasmic component containing special RNAs and proteins, and is located in specific regions of oocytes and embryos. Only...
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R-loop and diseases: the cell cycle matters
The cell cycle is a crucial biological process that is involved in cell growth, development, and reproduction. It can be divided into G1, S, G2, and...
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Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
Frontotemporal lobar degeneration (FTLD) is a group of disorders characterized by degeneration of the frontal and temporal lobes, leading to...
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Revisiting a Telencephalic Extent of the Ascending Reticular Activating System
Is the cerebrum involved in its own activation to states of attention or arousal? “Telencephalon” is a term borrowed from embryology to identify not...
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Physiological and pathological effects of phase separation in the central nervous system
Phase separation, also known as biomolecule condensate, participates in physiological processes such as transcriptional regulation, signal...
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Par-4 in Cell Cycle Regulation
Cell cycle must be carefully controlled to ensure genetic materials are replicated once and only once per cycle and equal sister chromatid...
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Germinal development in embryonic rediae of the hemiuroid digenean Bunocotyle progenetica: an ultrastructural study
Embryonic development of reproductive organs in rediae of the digenean Bunocotyle progenetica was studied using transmission electron microscopy. The...
