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Comparative analysis of metacyclogenesis and infection curves in different discrete ty** units of Trypanosoma cruzi
Chagas disease (CD), caused by the complex life cycle parasite Trypanosoma cruzi , is a global health concern and impacts millions globally. T. cruzi ’s...
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Chagas Disease and Leishmaniasis, Sympatric Zoonoses Present in Human from Rural Communities of Venezuela
PurposeTrypanosoma cruzi and Leishmania spp. coexist in several endemic areas, and there are few studies of Chagas disease and leishmaniasis...
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Slight temperature changes cause rapid transcriptomic responses in Trypanosoma cruzi metacyclic trypomastigotes
BackgroundSevere changes in temperature can affect the behavior and ecology of some infectious agents. Trypanosoma cruzi is a protozoan that causes...
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“Mi Casa, Tu Casa”: the coati nest as a hub of Trypanosoma cruzi transmission in the southern Pantanal biome revealed by molecular blood meal source identification in triatomines
BackgroundThe study of the ecology of Trypanosoma cruzi is challenging due to its extreme adaptive plasticity, resulting in the parasitism of...
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Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns
Despite the different perspectives by diverse research sectors spanning several decades, aging research remains uncharted territory for human beings....
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Molecular Characterization of Four Mexican Isolates of Trypanosoma cruzi and Their Profile Susceptibility to Nifurtimox
PurposeThe objective of this study was to molecularly characterize Mexican isolates of T. cruzi obtained from infected triatomine bugs (the vectors...
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Infection susceptibility and vector competence of Rhodnius robustus Larrousse, 1927 and R. pictipes Stal, 1872 (Hemiptera, Reduviidae, Triatominae) for strains of Trypanosoma cruzi (Chagas, 1909) (Kinetoplastida, Trypanosomatidae) I, II and IV
BackgroundRhodnius robustus and Rhodnius pictipes are vectors of Trypanosoma cruzi, the etiologic agent of Chagas disease (CD), that are found in...
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Remarkable genetic diversity of Trypanosoma cruzi and Trypanosoma rangeli in two localities of southern Ecuador identified via deep sequencing of mini-exon gene amplicons
BackgroundTrypanosoma cruzi , the causative agent of Chagas disease, and T. rangeli are kinetoplastid parasites endemic to Latin America. Although...
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Trypanosoma Cruzi: An Ancient and Successful Enzootic Parasite
Despite the growing global awareness of the importance of environmental preservation and the interdependence of plant, animal, and environmental...
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Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment
BackgroundComponents of the antioxidant defense system in Trypanosoma cruzi are potential targets for new drug development. Superoxide dismutases...
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High Trypanosoma cruzi prevalence in armadillo (Zaedyus pichiy; Xenarthra: Chlamyphoridae) populations from Mendoza, Argentina
Armadillos are considered important reservoir hosts for Trypanosoma cruzi , the causative agent of Chagas disease . The first report of T. cruzi ...
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Differential expression of proteins in genetically distinct Trypanosoma cruzi samples (TcI and TcII DTUs) isolated from chronic Chagas disease cardiac patients
BackgroundTrypanosoma cruzi , a hemoflagellate protozoan parasite and the etiological agent of Chagas disease (CD), exhibits great genetic and...
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Over-dispersed Trypanosoma cruzi parasite load in sylvatic and domestic mammals and humans from northeastern Argentina
BackgroundThe distribution of parasite load across hosts may modify the transmission dynamics of infectious diseases. Chagas disease is caused by a...
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Prevalence of Trypanosoma lainsoni and its effects of parasitism on the health of non-volant small mammals from the Brazilian Cerrado
Small mammals are important hosts and/or reservoirs of Trypanosoma spp. This study aimed to verify the prevalence of Trypanosoma spp. in non-volant...
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Identification of blood-feeding sources in Panstrongylus, Psammolestes, Rhodnius and Triatoma using amplicon-based next-generation sequencing
BackgroundTriatomines are hematophagous insects that play an important role as vectors of Trypanosoma cruzi , the causative agent of Chagas disease....
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Dogs and Their Role in the Eco-epidemiology of Chagas Disease
Chagas disease, caused by infection with Trypanosoma cruzi, is an important disease of humans and dogs in the Americas. Here, we review aspects of...
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Rhodnius (Stål, 1859) (Hemiptera, Triatominae) genus in Bolivian Amazonia: a risk for human populations?
BackgroundChagas disease, one of the most important neglected tropical diseases in the countries of Latin America, is considered to be a particularly...
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Genoty** of Trypanosoma cruzi from Clinical Samples by Multilocus Conventional PCR
By the most recent nomenclature, Trypanosoma cruzi isolates are classified into six discrete ty** units (DTUs)—T. cruzi I to T. cruzi VI and TcBat....
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ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease
Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans -sialidase (TS) antigens either in the form of recombinant protein, encoded in...
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Life Cycle of Pathogenic Protists: Trypanosoma cruzi
Trypanosoma cruzi is the agent of Chagas disease with a high prevalence in Latin America. This protozoan presents a complex life cycle in the...