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Dolutegravir-induced growth and lifespan effects in Caenorhabditis elegans
BackgroundIntegrase strand transfer inhibitor (INSTIs)-based combination antiretroviral treatment in people living with HIV (PLWH) has been...
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Overexpression of Motopsin, an Extracellular Serine Protease Related to Intellectual Disability, Promotes Adult Neurogenesis and Neuronal Responsiveness in the Dentate Gyrus
Motopsin, a serine protease encoded by PRSS12 , is secreted by neuronal cells into the synaptic clefts in an activity-dependent manner, where it...
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Physicochemical Characterization of Three Active Pharmaceutical Ingredients for Compound Glycyrrhizin Solid Formulation and Compatibility Analysis via Thermal and Non-thermal Techniques
PurposeThis study aimed to develop evaluation methods for multicomponent system interactions between drug excipients of three active pharmaceutical...
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Dolutegravir Inhibition of Matrix Metalloproteinases Affects Mouse Neurodevelopment
Dolutegravir (DTG) is a first-line antiretroviral drug (ARV) used in combination therapy for the treatment of human immunodeficiency virus type-1...
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Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier
BackgroundAppropriate interactions between antiretroviral therapies (ART) and drug transporters and metabolizing enzymes at the blood brain barrier...
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Enhanced Solubility and Bioavailability of Dolutegravir by Solid Dispersion Method: In Vitro and In Vivo Evaluation—a Potential Approach for HIV Therapy
Being a candidate of BCS class II, dolutegravir (DTG), a recently approved antiretroviral drug, possesses solubility issues. The current research was...
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New Antiretroviral Agents for HIV Infection
The development of antiretroviral drugs for treatment of human immunodeficiency virus (HIV) infection is the most remarkable achievement in medical...
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Applicability of Reddish-Orange Light Emitting Samarium (III) Complexes for Biomedical and Multifunctional Optoelectronic Devices
Six crimson samarium (III) complexes based on β-ketone carboxylic acid and ancillary ligands were synthesized by adopting the grinding technique. All...
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Combined cART including Tenofovir Disoproxil, Emtricitabine, and Dolutegravir has potent therapeutic effects in HIV-1 infected humanized mice
HIV-1 reservoirs persist in the presence of combined antiretroviral therapy (cART). However, cART has transformed HIV-1 infection into a chronic...
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Tenofovir alafenamide plus dolutegravir as a switch strategy in HIV-infected patients: a pilot randomized controlled trial
BackgroundCurrently, two-drug antiretroviral regimens are emerging fields in life-long treatment in people living with HIV.
Objectives ...
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Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in Microglia
Despite the ability of combination antiretroviral therapy (cART) to suppress viremia, there is persistence low levels of HIV proteins such as...
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Relationship between drug targets and drug-signature networks: a network-based genome-wide landscape
Drugs produce pharmaceutical and adverse effects that arise from the complex relationship between drug targets and signatures; by considering such...
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Viral suppression rate at operation triple zero (Otz) and regular art follow-Up programs and associated factors among adolescent clients of Addis Ababa Ethiopia: a comparative cross-sectional study
Background- Viral suppression is the main goal of currently available treatment and it is used as a primary indicator of successful treatment for...
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A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human immunodeficiency virus (HIV). There are currently four approved...
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Use of programmed cell death protein 1 (PD-1) inhibitor therapy in HIV-infected patients with advanced cancer: a single-center study from China
BackgroundAnti-PD-1 antibodies have been approved for treating several cancer. However, data regarding the safety and efficacy of these agents in...
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Learning from cerebrospinal fluid drug-resistant HIV escape-associated encephalitis: a case report
BackgroundIn the era of antiretroviral therapy (ART), central nervous system (CNS) complications in patients with human immunodeficiency virus (HIV)...
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Renal function and lipid metabolism in Japanese HIV-1-positive individuals 288 weeks after switching from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate: a single-center, retrospective cohort study
BackgroundContinued use of tenofovir disoproxil fumarate (TDF), an antiretroviral drug, causes renal function decline and tubular damage in...
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FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis
Doxorubicin is a common chemotherapeutic agent in clinic, but myocardial toxicity limits its use. Fibroblast growth factor (FGF) 10, a...
