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Intestinal mucus components and secretion mechanisms: what we do and do not know
Damage to the colon mucus barrier, the first line of defense against microorganisms, is an important determinant of intestinal diseases such as...
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Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats
The pharmacological inhibition of glial activation is one of the new approaches for combating neuropathic pain in which the role of glia in the...
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Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin
Calsenilin is a calcium ion (Ca 2+ )-binding protein involved in regulating the intracellular concentration of Ca 2+ , a second messenger that controls...
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Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington’s disease
The transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a multifunctional neuronal calcium sensor (NCS) that...
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DREAM-Dependent Activation of Astrocytes in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of unknown origin and characterized by a relentless loss of motor neurons that...
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Nitric Oxide Modulated the Expression of DREAM/Calsenilin/KChIP3 in Inflammatory Pain of Rats
Downstream regulatory element antagonistic modulator (DREAM) is a critical transcriptional repressor for pain modulation. The role of nitric oxide...
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Nuclear calcium signalling in the regulation of brain function
Synaptic activity initiates biochemical processes that have various outcomes, including the formation of memories, increases in neuronal survival and...
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Prominin-2 and Other Relatives of CD133
Several molecules related to prominin-1/CD133, which was first characterized as a marker of mouse neuroepithelial stem cells and human hematopoietic...
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Understanding the physiological roles of the neuronal calcium sensor proteins
Calcium signalling plays a crucial role in the control of neuronal function and plasticity. Changes in neuronal Ca 2+ concentration are detected by Ca 2+...
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Nuclear Calcium Signaling
Calcium is the major intracellular messenger linking synaptic activity in neurons to gene expression to control diverse functions including adaptive...
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Structural and functional characteristics of potassium channels and their role in neuroplasticity
This review is focused on the molecular structure of potassium channels in the mammalian CNS. A key role in the regulation of neuronal excitation is...
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Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes
Kv4 low voltage–activated A-type potassium channels are widely expressed in excitable cells, where they control action potential firing, dendritic...
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Calcium Regulation by EF-hand Protein in the Brain
The EF-hand containing calcium-binding proteins (CaBP) form a large family of proteins that is continuously growing, adding more complexity to...
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Modulation by Clam**: Kv4 and KChIP Interactions
The rapidly inactivating (A-type) potassium channels regulate membrane excitability that defines the fundamental mechanism of neuronal functions such...
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Distribution of Downstream Regulatory Element Antagonist Modulator (DREAM) in Rat Spinal Cord and Upregulation of Its Expression during Inflammatory Pain
A previous knockout study revealed the critical role of downstream regulatory element antagonist modulator (DREAM) in pain processing in the spinal...
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To the Nucleus with Proteomics
In this chapter we review proteomic studies performed on purified postsynaptic density (PSD) fractions and analyze what their results reveal about...
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Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling
In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal...
