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BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). Due to its...
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Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Purpose of ReviewCastration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to...
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The DNA Damage Checkpoint
The DNA damage response (DDR), also known as the DNA damage checkpoint (DNADC) acts to prevent cells with damaged DNA from entering mitosis. Kinds of...
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DNA damage repair and cancer immunotherapy
Cells are exposed to multiple endogenous and exogenous stresses daily, some of which can induce DNA damage, a major source of genomic instability. To...
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Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375/PRKDC Axis and PD-L1 phosphorylation
BackgroundTargeted drugs are not quite effective for prolonging the survival of patients with gastric cancer due to off-target effects as well as...
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Phase separation of low-complexity domains in cellular function and disease
In this review, we discuss the ways in which recent studies of low-complexity (LC) domains have challenged our understanding of the mechanisms...
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Estrogen receptor inhibition mediates radiosensitization of ER-positive breast cancer models
Endocrine therapy (ET) is an effective first-line therapy for women with estrogen receptor-positive (ER + ) breast cancers. While both ionizing...
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Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutations
Constant challenges for the treatment of mantle cell lymphoma (MCL) remain to be recurrent relapses and therapy resistance, especially in patients...
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SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes
BackgroundPrognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC...
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Network Biology Approaches to Uncover Therapeutic Targets Associated with Molecular Signaling Pathways from circRNA in Postoperative Cognitive Dysfunction Pathogenesis
Postoperative cognitive dysfunction (POCD) is a cognitive deterioration and dementia that arise after a surgical procedure, affecting up to 40% of...
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The activation mechanisms of master kinases in the DNA damage response
DNA damage can be introduced by intrinsic or extrinsic stimuli and threaten the transmission of genetic information and ultimately, survival....
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Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a prognostic model
BackgroundThe prognostic management of bladder cancer (BLCA) remains a great challenge for clinicians. Recently, bulk RNA-seq sequencing data have...
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Targeting the Transcription Factors of ROS Tumorigenic Pathways as a Therapeutic Strategy in Cancer
Emerging of reactive oxygen species (ROS) on the earth with the first oxygen molecule in the atmosphere around 2.4–3.8 billion years ago, and they...
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Targeting the Transcription Factors of ROS Tumorigenic Pathways as a Therapeutic Strategy in Cancer
Emerging of reactive oxygen species (ROS) on the earth with the first oxygen molecule in the atmosphere around 2.4–3.8 billion years ago, and they...
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ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer
BackgroundAZD0156 is an oral inhibitor of ATM, a serine threonine kinase that plays a key role in DNA damage response (DDR) associated with...
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UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target
BackgroundN-end rule ubiquitination pathway is known to be disrupted in many diseases, including cancer. UBR5, an E3 ubiquitin ligase, is mutated...
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Post-translational Mechanisms of Zinc Signalling in Cancer
Three groups of proteins are actively involved in the control of intracellular zinc, consisting of ZIP channels (SLC39A), ZnT transporters (SLC30A),...
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Telomeres, Telomerase, and Aging
We present a list of basic functions to ensure viability of living systems and highlight the roles that telomerase plays. Telomere length is an...
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Heterogeneity of triple negative breast cancer: Current advances in subty** and treatment implications
As the field of translational ‘omics has progressed, refined classifiers at both genomic and proteomic levels have emerged to decipher the...
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Targeting replication stress in cancer therapy
Replication stress is a major cause of genomic instability and a crucial vulnerability of cancer cells. This vulnerability can be therapeutically...
