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Prognostic value of a novel biomarker combining DNA ploidy and tumor burden score for initially resectable liver metastases from patients with colorectal cancer
BackgroundColorectal cancer liver metastases (CRLM) has not been identified as a unified disease entity due to the differences in the severity of...
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Ploidy Modification for Plant Breeding Using In Vitro Organogenesis: A Case in Eggplant
The use of antimitotic agents such as colchicine has been common to obtain polyploid organisms. However, this approach entails certain problems, from...
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Cytogeography of the Polyploid Complex Bassia prostrata s. l. (Chenopodiaceae) Based on Genome Size Analysis and PCR-RFLP cpDNA
AbstractThe cytogeography of the polyploid complex Bassia prostrata s. l. was studied by flow cytometry (FCM) on material from 39 populations in...
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Single-mitosis dissection of acute and chronic DNA mutagenesis and repair
How chronic mutational processes and punctuated bursts of DNA damage drive evolution of the cancer genome is poorly understood. Here, we demonstrate...
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Sequencing of genes of drug response in tumor DNA and implications for precision medicine in cancer patients
Tumor DNA sequencing is becoming standard-of-care for patient treatment decisions. We evaluated genotype concordance between tumor DNA and genomic...
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Flow Cytometry in the Diagnosis of Hematological Neoplasms and Other Cancers
Flow cytometry (FCM) is a powerful technology that can provide rapid multiparameter analysis of single cells. With the significant improvement in...
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Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes
BackgroundSeveral studies have reported an association between male infertility and aberrant sperm DNA methylation patterns, in particular in...
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Genome wide DNA methylation analysis identifies novel molecular subgroups and predicts survival in neuroblastoma
BackgroundNeuroblastoma is the most common malignancy in infancy, accounting for 15% of childhood cancer deaths. Outcome for the high-risk disease...
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Specifics of Transfer of DNA Markers of Wild Allotetraploid Potato Species Solanum stoloniferum to Backcross Progenies Depending on Their Subgenomic Location and Used Schemes of Introgression
AbstractGenomic difference between wild allotetraploid potato species Solanum stoloniferum Schltdl et Bouchet (genome AABB) and S. tuberosum L....
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Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content
BackgroundCirculating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it...
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Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9
BackgroundPrimary liver cancer has significant intratumor genetic heterogeneity (IGH), which drives cancer evolution and prevents effective cancer...
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Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and challenging clinical management. Through a large series of...
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Evolutionary characterization of lung adenocarcinoma morphology in TRACERx
Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade lepidic tumors through to mid-grade acinar and papillary and...
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Non-invasive preimplantation genetic testing for conventional IVF blastocysts
BackgroundPrevious studies suggested that non-invasive preimplantation genetic testing (niPGT) for intracytoplasmic sperm injection (ICSI)...
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Genome-wide analysis reveals allelic variation and chromosome copy number variation in paromomycin-resistant Leishmania donovani
In the absence of adequate diagnosis and treatment, leishmaniasis remains a major public health concern on a global scale. Drug resistance remains a...
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Genoty** of Interspecific Brassica rapa Hybrids Implying β-Tubulin Gene Intron Length Polymorphism (TBP/cTBP) Assessment
The Crucifers family (Brassicaceae) includes a large number of economically important crops, particularly Brassica rapa , which is a widely used model...
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The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability
BackgroundCancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor...
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Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Mutation accumulation in somatic cells contributes to cancer development and is proposed as a cause of aging. DNA polymerases Pol ε and Pol δ...
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Eupolyploidy As a Mode in Plant Speciation
AbstractWhen discussing phenomena of whole genome duplication, the terms “neopolyploid,” “mesopolyploid,” and “paleopolyploid” are used in their...
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Thrombopoietin receptor agonist antibody for treating chemotherapy-induced thrombocytopenia
BackgroundThrombocytopenia is a common complication in cancer patients undergoing chemotherapy. Chemotherapy-induced thrombocytopenia (CIT) leads to...
