Search
Search Results
-
MutS and MutL sliding clamps in DNA mismatch repair
DNA mismatch repair (MMR) corrects mispair nucleotides that arise from polymerase misincorporation. Highly conserved MutS (MSH) and MutL (MLH/PMS)...
-
DNA Damage and DNA Repair
This chapter describes in more detail the various kinds of DNA damage that can cause mutations and chromosomal alterations as well as the...
-
DNA mismatch repair system regulates the expression of PD-L1 through DNMTs in cervical cancer
BackgroundCervical cancer (CC) is a potential clinical application of PD-1/PD-L1 inhibitor. We aimed to study the mechanism of DNA mismatch repair...
-
Mitochondrial DNA copy number plays opposing roles in T-lymphocyte infiltration of colorectal cancer based on mismatch repair status: new directions for immunotherapy?
BackgroundResearchers have previously reported that mitochondrial DNA copy number (mtDNA-CN) can play different roles in microsatellite...
-
Evolutionary origin of germline pathogenic variants in human DNA mismatch repair genes
BackgroundMismatch repair (MMR) system is evolutionarily conserved for genome stability maintenance. Germline pathogenic variants (PVs) in MMR genes...
-
A tumor focused approach to resolving the etiology of DNA mismatch repair deficient tumors classified as suspected Lynch syndrome
Routine screening of tumors for DNA mismatch repair (MMR) deficiency (dMMR) in colorectal (CRC), endometrial (EC) and sebaceous skin (SST) tumors...
-
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding homopolymers in target genes. Curiously, the MMR genes MutS...
-
The prevalence of lynch syndrome (DNA mismatch repair protein deficiency) in patients with primary localized prostate cancer using immunohistochemistry screening
BackgroundProstate cancer is one of the most heritable human cancers. Lynch syndrome is an autosomal dominant inheritance caused by germline...
-
CT-based deep learning model for the prediction of DNA mismatch repair deficient colorectal cancer: a diagnostic study
BackgroundStratification of DNA mismatch repair (MMR) status in patients with colorectal cancer (CRC) enables individual clinical treatment decision...
-
Mismatch Repair Status Characterization as an Immune-Related Biomarker in Oncology
The mismatch repair (MMR) system recognizes and corrects DNA bases misincorporation formed during replication and recombination, thus maintaining...
-
Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques
BackgroundNaturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and are useful models for...
-
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden (TMB) and sensitivity to immune checkpoint blockade (ICB)...
-
GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity
BackgroundDNA double-strand break (DSB) induction and repair are important events for determining cell survival and the outcome of cancer...
-
Comparison of standard mismatch repair deficiency and microsatellite instability tests in a large cancer series
BackgroundThe tumor-agnostic indication of immune checkpoint inhibitors to treat cancers with mismatch repair deficiency (dMMR)/microsatellite...
-
Roles of NRF2 in DNA damage repair
PurposeThe transcription factor NF-E2-related factor 2 (NRF2) is a master regulator widely involved in essential cellular functions such as DNA...
-
Evaluating mismatch repair deficiency in colorectal cancer biopsy specimens
Mismatch repair (MMR) testing on all new cases of colorectal cancer (CRC) has customarily been preferably performed on surgical specimens, as more...
-
Death receptors 4/5 mediate tumour sensitivity to natural killer cell-mediated cytotoxicity in mismatch repair deficient colorectal cancer
BackgroundIdentifying the target of natural killer (NK) cells in colorectal cancer (CRC) is critical for optimising the clinical use of NK...
-
Role of DNA Mismatch Repair Genes in Colorectal Cancer
Colorectal cancer (CRC) is the third most known type of cancer in develo** countries and is one of the leading causes of deaths around the world....
-
Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer
BackgroundThe determinants of metastasis in mismatch repair deficiency with high levels of microsatellite instability (MSI-H) in colorectal cancer...
-
Gadd45 in DNA Demethylation and DNA Repair
Growth arrest and DNA damage 45 (Gadd45) family genes, Gadd45A, Gadd45B, and GADD45 G are implicated as stress sensors that are rapidly induced upon...