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Immunization Strategies Against Clostridioides difficile
Clostridioides difficile (C. difficile) infection (CDI) is an important healthcare but also a community-associated disease. CDI is considered a...
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Immunization with a multi-antigen targeted DNA vaccine eliminates chemoresistant pancreatic cancer by disrupting tumor-stromal cell crosstalk
BackgroundPancreatic ductal adenocarcinoma (PDAC) is characterised by limited responses to chemoimmunotherapy attributed to highly desmoplastic tumor...
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Potential of an anti-bevacizumab idiotype scFv DNA-based immunization to elicit VEGF-binding antibody response
Anti-idiotype antibodies have been considered for vaccination approaches against different diseases, including cancers. Based on that, we previously...
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Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection
Antigens from viruses or immunizations can persist or are archived in lymph node stromal cells such as lymphatic endothelial cells (LEC) and...
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Insights into the protective immune response by immunization with full-length recombinant TprK protein: cellular and humoral responses
Syphilis has resurged in many countries, which has called attention to vaccine development. Based on the immunization-based rabbit model of infection...
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The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
Immunization with Plasmodium sporozoites, either attenuated or administered under the cover of an antimalarial drug, can induce strong protection...
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Impact of a Plasmid DNA-Based Alphavirus Vaccine on Immunization Efficiency
Alphavirus Alphaviruses vectors have been engineered for high-level gene expression relying originally on replication-deficient recombinant...
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Vaccines, Vaccination, and Immunization
Vaccines are based on antigens from pathogenic microbes or the toxins they produce that induce adaptive immune responses for protection from...
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Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens
An effective human immunodeficiency virus type I (HIV-1) vaccine that robustly elicits broadly neutralizing antibodies (bnAbs) against HIV-1 envelope...
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Intranasal immunization of mice with chimera of Salmonella Typhi protein elicits protective intestinal immunity
Development of safe, highly effective and affordable enteric fever vaccines is a global health priority. Live, oral typhoid vaccines induce strong...
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DNA based neoepitope vaccination induces tumor control in syngeneic mouse models
Recent findings have positioned tumor mutation-derived neoepitopes as attractive targets for cancer immunotherapy. Cancer vaccines that deliver...
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Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that poses a severe threat to humans due to its high morbidity and the lack of viable...
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DNA Vaccine Encoding the Artificial T-Cell Polyepitope Immunogen of Tick-Borne Encephalitis Virus
A promising approach to the development of new means for preventing infection caused by tick-borne encephalitis virus can be DNA vaccines encoding...
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Immunization against arthropod protein impairs transmission of rickettsial pathogen from ticks to the vertebrate host
Human anaplasmosis caused by Anaplasma phagocytophilum is one of the most common tick-borne diseases in the United States. The black-legged ticks, Ixod...
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Immunization of Hens
Immunization of hens is the critical step in generating biologically active antibodies of high specificity and avidity in large amounts. A number of...
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Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota
Durable antibody immunity depends on long-lived plasma cells (LLPCs) that primarily reside in the bone marrow (BM). However, due to LLPC rarity, it...
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Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice
Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a...
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A linear SARS-CoV-2 DNA vaccine candidate reduces virus shedding in ferrets
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has caused more than...
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XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner
BackgroundDifferences in male vs. female immune responses are well-documented and have significant clinical implications. While the immunomodulatory...
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Neonatal Immunization
Neonatal period is a once in a lifetime opportunity for immunization. There is already a common practice to vaccinate neonates against tuberculosis,...