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1. Reconfigurable Two-Dimensional DNA Molecular Arrays

   In biology, molecular cascade signaling is an essential tool to mediate various pathways and downstream behaviors. Mimicking these molecular cascades...

   Donglei Yang, Fan Xu, Pengfei Wang in DNA and RNA Origami

   Protocol 2023
   

2. Fabrication of Multilayer Microfluidic Arrays for Passive, Efficient DNA Trap** and Profiling

   Trace amounts of cell-free DNA containing cancer-specific biomarkers can be found in blood plasma. Detection of these biomarkers holds tremendous...

   Christine M. O’Keefe, Tza-Huei Jeff Wang in Microfluidic Systems for Cancer Diagnosis

   Protocol 2023
   

3. The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D

   Focal Cortical Dysplasia (FCD) is a frequent cause of drug-resistant focal epilepsy in children and young adults. The international FCD...

   Dan-Dan Wang, Mitali Katoch, ... Yue-Shan Piao in Acta Neuropathologica Communications

   Article Open access 09 August 2023
   

4. DNA choreography: correlating mobility and organization of DNA across different resolutions from loops to chromosomes

   The dynamics of DNA in the cell nucleus plays a role in cellular processes and fates but the interplay of DNA mobility with the hierarchical levels...

   Maruthi K. Pabba, Janis Meyer, ... M. Cristina Cardoso in Histochemistry and Cell Biology

   Article Open access 17 May 2024
   

5. Cellular Uptake of DNA Origami

   This chapter discusses the methods involved in achieving and analyzing cellular uptake of DNA origami. While cells naturally internalize substances...

   Maartje M. C. Bastings in DNA and RNA Origami

   Protocol 2023
   

6. Development of Specialized Microelectrode Arrays with Local Electroporation Functionality

   When a cell or tissue is exposed to a pulsed electric field (100–1000 V/cm), the cellular membrane permeabilizes for biomolecules that cannot pass an...

   Andrea Kauth, Anne-Kathrin Mildner, ... Sven Ingebrandt in Annals of Biomedical Engineering

   Article Open access 16 June 2023
   

7. Evaluating Reliability of DNA Methylation Measurement

   DNA methylation is a widely studied epigenetic phenomenon. Alterations in methylation patterns influence human phenotypes and risk of disease. The...

   Rui Cao, Weihua Guan in Epigenome-Wide Association Studies

   Protocol 2022
   

8. DNA Origami: Recent Progress and Applications

   This chapter explores the basic concept of DNA origami and its various types. By showing the progress made in structural DNA nanotechnology during...

   Michael Haydell, Yinzhou Ma in DNA and RNA Origami

   Protocol 2023
   

9. DNA Methylation and Epigenetic Aging Biomarkers in Huntington’s Disease

   DNA methylation is an epigenetic modification that plays critical roles in several important processes, including regulation of transcription,...

   Elizabeth A. Thomas in Biomarkers for Huntington's Disease

   Chapter 2023
   

10. Race-specific coregulatory and transcriptomic profiles associated with DNA methylation and androgen receptor in prostate cancer

    Background

    Prostate cancer is a significant health concern, particularly among African American (AA) men who exhibit higher incidence and mortality...

    Swathi Ramakrishnan, Eduardo Cortes-Gomez, ... Anna Woloszynska in Genome Medicine

    Article Open access 02 April 2024
    

11. DNA Condensation Processes Mediated by Metal-Based Drug Entities and Morphological Studies

    The term ‘condensation’ is used to depict aggregates of a finite size with orderly morphology that are provoked by chemical agents, multivalent...

    Farukh Arjmand, Sartaj Tabassum, Huzaifa Yasir Khan in Advances and Prospects of 3-d Metal-Based Anticancer Drug Candidates

    Chapter 2024
    

12. High-throughput spatiotemporal monitoring of single-cell secretions via plasmonic microwell arrays

    Methods for the analysis of cell secretions at the single-cell level only provide semiquantitative endpoint readouts. Here we describe a microwell...

    Saeid Ansaryan, Yen-Cheng Liu, ... Hatice Altug in Nature Biomedical Engineering

    Article Open access 03 April 2023
    

13. Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy

    Background

    DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and...

    Ricardo Martins-Ferreira, Bárbara Leal, ... Esteban Ballestar in Clinical Epigenetics

    Article Open access 28 December 2022
    

14. Blood DNA methylation and liver cancer in American Indians: evidence from the Strong Heart Study

    Purpose

    Liver cancer incidence among American Indians/Alaska Natives has risen over the past 20 years. Peripheral blood DNA methylation may be...

    Monique Slowly, Arce Domingo-Relloso, ... Hui-Chen Wu in Cancer Causes & Control

    Article Open access 27 November 2023
    

15. Parallel Functionalization of DNA Origami

    DNA origami enables the creation of large supramolecular structures, with precisely defined features at the nanoscale. The concept thus naturally...

    Rasmus P. Thomsen, Rasmus S. Sørensen, Jørgen Kjems in DNA and RNA Origami

    Protocol 2023
    

16. Two-Dimensional DNA Origami Lattices Assembled on Lipid Bilayer Membranes

    Molecular self-assembly has attracted much attention as a method to create novel supramolecular architectures. The scaffolded DNA origami method has...

    Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo in DNA and RNA Origami

    Protocol 2023
    

17. DNA packaging by molecular motors: from bacteriophage to human chromosomes

    Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always far exceeds the dimensions of the cells that contain it....

    Bram Prevo, William C. Earnshaw in Nature Reviews Genetics

    Article 17 June 2024
    

18. Fathers’ preconception smoking and offspring DNA methylation

    Background

    Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted...

    Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, ... John W. Holloway in Clinical Epigenetics

    Article Open access 31 August 2023
    

19. Incorporation of DNA methylation quantitative trait loci (mQTLs) in epigenome-wide association analysis: application to birthweight effects in neonatal whole blood

    Background

    Epigenome-wide association studies (EWAS) have helped to define the associations between DNA methylation and many clinicopathologic and...

    Shaobo Li, Nicholas Mancuso, ... Joseph L. Wiemels in Clinical Epigenetics

    Article Open access 01 December 2022
    

20. Creation and validation of the first infinium DNA methylation array for the human imprintome

    Background

    Differentially methylated imprint control regions (ICRs) regulate the monoallelic expression of imprinted genes. Their epigenetic...

    Natalia Carreras-Gallo, Varun B. Dwaraka, ... Cathrine Hoyo in Epigenetics Communications

    Article Open access 10 July 2024